Evidence map›Paper›PMID 36967391›Full record

ArticleJournal of clinical monitoring and computing2023

Clinical validation of an adapted Eleveld Model for high-dose propofol treatments for depression.

C Lybbert, J Huang, K G Jones, B J Mickey, S Tadler, D Odell, J Stanford, K Kuck

Erratum issuedAbstract read
PubMed Publisher
In one paragraph

Article in Journal of clinical monitoring and computing, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

C LybbertDepartment of Anesthesiology, University of Utah, Salt Lake City, UT, USA. carterlybbert46@gmail.com.
J HuangDepartment of Anesthesiology, University of Utah, Salt Lake City, UT, USA.
K G JonesDepartment of Psychiatry, Huntsman Mental Health Institute, University of Utah, Salt Lake City, UT, USA.
B J MickeyDepartment of Anesthesiology, University of Utah, Salt Lake City, UT, USA.
S TadlerDepartment of Anesthesiology, University of Utah, Salt Lake City, UT, USA.
D OdellDepartment of Anesthesiology, University of Utah, Salt Lake City, UT, USA.
J StanfordHuntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.
K KuckDepartment of Anesthesiology, University of Utah, Salt Lake City, UT, USA.
University of Utah · USHuntsman Cancer Institute · US

Funding

Center for Clinical and Translational Science, University of Utah UL1TR002538
6 · The paper itself

Abstract

Repeated administration of high doses of propofol to patients with treatment-resistant depression (TRD) has been shown to produce antidepressant effects in small clinical trials. These effects can be elicited when the patient's EEG burst-suppression ratio (BSR) is maintained at 70-90% for 15 min in repeated treatments. This deep anesthesia domain lies beyond the range of current propofol pharmacokinetic/pharmacodynamic (PK/PD) models. In this study, we adapt the Eleveld model for use at deep anesthesia levels with a BSR endpoint, with the goal of aiding the estimation of the dosage of propofol needed to achieve 70-90% BSR for 15 min. We test the ability of the adapted model to predict BSR for these treatments. Twenty participants underwent 6-9 treatments of high doses of propofol (5-9 of which were included in this analysis) for a total of 115 treatments. To adapt the Eleveld model for this endpoint, we optimized the model parameters Ke0, γ and C

Indexed as

PropofolAnesthetics, IntravenousDepressionHumansInfusions, IntravenousAnesthetics, IntravenousPropofolBurst suppressionPharmacodynamicsPropofolTreatment-resistant depression

Identifiers

PMID36967391
OpenAlexW4360978492

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.