Evidence map›Paper›PMID 36967080›Full record

ArticleExperimental eye research2023

Collagen XII regulates stromal wound closure.

Christopher Donovan, Devon Cogswell, Mei Sun, Sheila Adams, Marcel Y Avila, Curtis E Margo, Manuel Koch, Edgar M Espana

Open access · greenAbstract read
In one paragraph

Article in Experimental eye research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
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  4. Short peptide 803sp inhibits the inflammatory response induced byFrontiers in cellular and infection microbiology · 2026
    Article
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  9. Dysfunctional latent transforming growth factor β activation after corneal injury in a classical Ehlers-Danlos model.Matrix biology : journal of the International Society for Matrix Biology · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 3 countries.

Christopher DonovanFrom the Cornea, External Disease Service, Department of Ophthalmology, USA.
Devon CogswellFrom the Cornea, External Disease Service, Department of Ophthalmology, USA.
Mei SunFrom the Cornea, External Disease Service, Department of Ophthalmology, USA.
Sheila AdamsFrom the Cornea, External Disease Service, Department of Ophthalmology, USA.
Marcel Y AvilaDepartament of Ophthalmology, Universidad Nacional de Colombia, Bogota, Colombia.
Curtis E MargoFrom the Cornea, External Disease Service, Department of Ophthalmology, USA; Pathology and Cell Biology, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.
Manuel KochInstitute for Dental Research and Oral Musculoskeletal Biology, Center for Biochemistry, University of Cologne, Cologne, Germany.
Edgar M EspanaFrom the Cornea, External Disease Service, Department of Ophthalmology, USA; Molecular Pharmacology and Physiology, USA. Electronic address: eespana@usf.edu.
NEA Foundation · USUniversidad Nacional de Colombia · COUniversity of Cologne · DEUniversity of South Florida · US

Funding

Regulation of tissue repair and scar formation by the stromal nicheR01EY034114 · NEI · UNIVERSITY OF SOUTH FLORIDA · PI Edgar Mauricio Espana · 2022 to 2026
$2.1M
Regulatory roles for collagen XII in establishment of corneal stromal structure and function and re-establishment after injuryR01EY029395 · NEI · UNIVERSITY OF SOUTH FLORIDA · PI ESPANA, EDGAR MAURICIO · 2018 to 2022
$1.8M
NEI NIH HHS R01 EY029395NEI NIH HHS R01 EY034114
6 · The paper itself

Abstract

The role of collagen XII in regulating injury repair and reestablishment of corneal function is unknown. This manuscript aims to investigate the role(s) of collagen XII in the repair of incisional and debridement injuries in an adult mouse model. Two different types of injury in wild type and Col12a1

Indexed as

CollagenCorneal InjuriesAnimalsCicatrixCorneaMiceMicroscopy, ElectronCollagenCollagen XIIFibroblastsRegenerationStromaWound

Identifiers

PMID36967080
PMCPMC10133200
OpenAlexW4360820773

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.