ArticleAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons2023
Persistent SARS-CoV-2-specific immune defects in kidney transplant recipients following third mRNA vaccine dose.
Erratum issuedOpen access · hybridAbstract read
In one paragraph
Article in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 15 papers.
0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 18 citations in OpenAlex.
- Article
- Longitudinal profiling of antigen receptor gene repertoire dynamics in kidney transplant recipients after multiple SARS-CoV-2 vaccinations.ImmunoHorizons · 2026Article
- Systems vaccinology identifies immunological correlates of SARS-CoV-2 vaccine response in solid organ transplant recipients.NPJ vaccines · 2025Article
- A third COVID-19 vaccine dose in kidney transplant recipients induces antibody response to vaccine and Omicron variants but shows limited Ig subclass switching.Microbiology spectrum · 2025Article
- Disease-associated B cells and immune endotypes shape adaptive immune responses to SARS-CoV-2 mRNA vaccination in human SLE.Nature immunology · 2025Article
- A Third COVID-19 Vaccine Dose in Kidney Transplant Recipients Induces Antibody Response to Vaccine and Omicron Variants but Shows Limited Ig Subclass Switching.bioRxiv : the preprint server for biology · 2024Article
- Neutralizing antibody responses and cellular responses against SARS-CoV-2 Omicron subvariants after mRNA SARS-CoV-2 vaccination in kidney transplant recipients.Scientific reports · 2024Article
- Epitope Mapping of SARS-CoV-2 Spike Antibodies in Vaccinated Kidney Transplant Recipients Reveals Poor Spike Coverage Compared to Healthy Controls.The Journal of infectious diseases · 2024Article
- T-cell receptor sequencing reveals selected donor-reactive CD8American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2024Article
- Castleman disease patients report mild COVID-19 symptoms and mount a humoral response to SARS-CoV-2 vaccination.Blood neoplasia · 2024Article
- Comparison of immune responses to SARS-CoV-2 spike following Omicron infection or Omicron BA.4/5 vaccination in kidney transplant recipients.Frontiers in immunology · 2024Article
- Severity of COVID-19 Pneumonia in Kidney Transplant Recipients According to SARS-CoV-2 Vaccination.Infection & chemotherapy · 2023Article
- Humoral and cellular immunity against different SARS-CoV-2 variants in patients with chronic kidney disease.Scientific reports · 2023Article
- Humoral and T cell Responses to SARS-CoV-2 Vaccine Booster and Anti-SARS-CoV-2 Monoclonal Antibodies in Patients With End-Stage Kidney Disease.Kidney international reports · 2023Article
- Kidney Transplant Recipients Develop Nasal Mucosal Antibodies to SARS-CoV-2 With ACE2-Inhibiting Activity Following mRNA Vaccination.Transplant infectious disease : an official journal of the Transplantation SocietyArticle
Corrections and comments
- Erratum issued
Authors and funding
31 authors at 7 institutions in 1 country.
William A WerbelDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. Electronic address: wwerbel1@jhmi.edu.
Andrew H KarabaDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Teresa Po-Yu ChiangDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Allan B MassieDepartment of Surgery, New York University Grossman School of Medicine, New York, New York, USA; Department of Population Health, New York University Grossman School of Medicine, New York, New York, USA.
Diane M BrownDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Natasha WatsonNational Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Maggie ChahoudDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Elizabeth A ThompsonDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Aileen C JohnsonDepartment of Surgery, Emory University, Atlanta, Georgia, USA.
Robin K AveryDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Willa V CochranDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Daniel WarrenDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Tao LiangDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Miguel FribourgTranslational Transplant Research Center, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Christopher HuertaDepartment of Medicine, Emory University, Atlanta, Georgia, USA.
Hady SamahaDepartment of Medicine, Emory University, Atlanta, Georgia, USA.
Sabra L KleinDepartment of Medicine, Emory University, Atlanta, Georgia, USA.
Maria P BettinottiDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
William A ClarkeDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Ioannis SitarasW. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
Nadine RouphaelDepartment of Medicine, Emory University, Atlanta, Georgia, USA.
Andrea L CoxDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA; Department of Medicine, Emory University, Atlanta, Georgia, USA; Bloomberg Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Justin R BaileyDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Andrew PekoszW. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
Aaron A R TobianDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Christine M DurandDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Nancy D BridgesNational Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Christian P LarsenDepartment of Surgery, Emory University, Atlanta, Georgia, USA.
Peter S HeegerDepartment of Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Dorry L SegevDepartment of Surgery, New York University Grossman School of Medicine, New York, New York, USA; Department of Population Health, New York University Grossman School of Medicine, New York, New York, USA.
CPAT investigators
Johns Hopkins University · USEmory University · USNational Institutes of Health · USNew York University · USBloomberg (United States) · USCedars-Sinai Medical Center · USIcahn School of Medicine at Mount Sinai · US
Funding
Vaccine Response and Immunotherapeutics SWGP30AI094189 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Anna Palmer Durbin · 2012 to 2026
$67.0MTransplant Tolerance in Non-Human PrimatesU19AI051731 · NIAID · UNIVERSITY OF WESTERN ONTARIO · PI LARSEN, CHRISTIAN P. · 2002 to 2022
$54.1MHOPE in Action: A Clinical Trial of HIV-to-HIV Liver TransplantationU01AI138897 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Christine Marie Durand, DORRY L. SEGEV · 2018 to 2026
$25.5MHOPE in Action: A clinical trial of HIV-to-HIV deceased donor kidney transplantationU01AI134591 · NIAID · JOHNS HOPKINS UNIVERSITY · PI DURAND, CHRISTINE MARIE, SEGEV, DORRY L. · 2017 to 2021
$11.0MVirology Resource CoreU54CA260492 · NCI · JOHNS HOPKINS UNIVERSITY · PI COX, ANDREA L, KLEIN, SABRA L. · 2020 to 2024
$10.4MSelective CD28 Blockade in Renal Transplant RecipientsU01AI138909 · NIAID · EMORY UNIVERSITY · PI BADELL, IDELBERTO RAUL, FORD, MANDY L · 2018 to 2022
$4.9MOptimizing Strategies to Overcome Kidney Xenograft RejectionR01AI126322 · NIAID · UNIVERSITY OF MINNESOTA · PI ADAMS, ANDREW B, TECTOR, A JOSEPH · 2016 to 2020
$4.6MAdvanced Research Training in Transplantation ScienceT32AI070081 · NIAID · EMORY UNIVERSITY · PI Mandy L Ford · 2006 to 2026
$3.1MReducing Disparities among Kidney Transplant RecipientsR01MD011682 · NIMHD · EMORY UNIVERSITY · PI ADAMS, ANDREW B, PATZER, RACHEL E · 2017 to 2021
$2.4MModulation of Herpes Simplex Virus Pathogenesis by Leucine Rich Repeat Kinase 2K08AI156021 · NIAID · JOHNS HOPKINS UNIVERSITY · PI KARABA, ANDREW HOOVER · 2021 to 2025
$994kPatient Oriented Research in Solid Organ TransplantationK24AI144954 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI SEGEV, DORRY L. · 2020 to 2024
$956kThe Landscape of Serious Infections following Kidney Transplantation in People Living with HIVK23AI157893 · NIAID · JOHNS HOPKINS UNIVERSITY · PI WERBEL, WILLIAM · 2021 to 2025
$847kNCI NIH HHS U54 CA260492NIAID NIH HHS K08 AI156021NIAID NIH HHS K23 AI157893NIAID NIH HHS K24 AI144954NIAID NIH HHS P30 AI094189NIAID NIH HHS R01 AI126322NIAID NIH HHS T32 AI070081NIAID NIH HHS U01 AI134591NIAID NIH HHS U01 AI138897NIAID NIH HHS U01 AI138909NIAID NIH HHS U19 AI051731NIMHD NIH HHS R01 MD011682
Abstract
Kidney transplant recipients (KTRs) show poorer response to SARS-CoV-2 mRNA vaccination, yet response patterns and mechanistic drivers following third doses are ill-defined. We administered third monovalent mRNA vaccines to n = 81 KTRs with negative or low-titer anti-receptor binding domain (RBD) antibody (n = 39 anti-RBD
Indexed as
COVID-19Kidney TransplantationAntibodies, ViralHumansmRNA VaccinesReceptors, Antigen, T-CellRNA, MessengerSARS-CoV-2Transplant RecipientsAntibodies, ViralmRNA VaccinesReceptors, Antigen, T-CellRNA, Messengerantibodyclinical trialimmunogenicitykidney transplantSARS-CoV-2vaccination
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.