Evidence map›Paper›PMID 36966391›Full record

ArticleCell reports2023

Time-resolved correlation of distributed brain activity tracks E-I balance and accounts for diverse scale-free phenomena.

Aditya Nanda, Graham W Johnson, Yu Mu, Misha B Ahrens, Catie Chang, Dario J Englot, Michael Breakspear, Mikail Rubinov

Erratum issuedAbstract read
In one paragraph

Article in Cell reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Aditya NandaDepartment of Biomedical Engineering, Vanderbilt University, Nashville, TN 37235, USA. Electronic address: aditya.nanda@vanderbilt.edu.
Graham W JohnsonDepartment of Biomedical Engineering, Vanderbilt University, Nashville, TN 37235, USA.
Yu MuInstitute of Neuroscience, Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai 200031, China.
Misha B AhrensJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA 20147, USA.
Catie ChangDepartment of Biomedical Engineering, Vanderbilt University, Nashville, TN 37235, USA; Department of Electrical and Computer Engineering, Vanderbilt University, Nashville, TN 37235, USA; Department of Computer Science, Vanderbilt University, Nashville, TN 37235, USA.
Dario J EnglotDepartment of Biomedical Engineering, Vanderbilt University, Nashville, TN 37235, USA; Department of Neurological Surgery, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Michael BreakspearSchool of Psychology, University of Newcastle, Callaghan, NSW 2308, Australia; School of Medicine and Public Health, University of Newcastle, Callaghan, NSW 2308, Australia.
Mikail RubinovDepartment of Biomedical Engineering, Vanderbilt University, Nashville, TN 37235, USA; Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA 20147, USA; Department of Computer Science, Vanderbilt University, Nashville, TN 37235, USA. Electronic address: mika.rubinov@vanderbilt.edu.

Funding

Overall: Eunice Kennedy Shriver Intellectual and Developmental Disabilities Research Center at VanderbiltP50HD103537 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Lea K Davis · 2020 to 2026
$10.3M
Integrative analysis of multiomic datasets for discovery of molecular underpinnings of large-scale human brain networksRF1MH125933 · NIMH · VANDERBILT UNIVERSITY · PI RUBINOV, MIKAIL · 2021 to 2021
$1.1M
Tracking brain arousal fluctuations for fMRI Big Data discoveryK22ES028048 · NIEHS · VANDERBILT UNIVERSITY · PI CHANG, CATHERINE ELIZABETH · 2018 to 2020
$606k
Directed connectivity analysis of resting-state SEEG and DWI to improve lateralization and localization in focal epilepsyF31NS120401 · NINDS · VANDERBILT UNIVERSITY · PI JOHNSON, GRAHAM WALTER · 2021 to 2022
$52k
Howard Hughes Medical InstituteNICHD NIH HHS P50 HD103537NIEHS NIH HHS K22 ES028048NIMH NIH HHS RF1 MH125933NINDS NIH HHS F31 NS120401
6 · The paper itself

Abstract

Much of systems neuroscience posits the functional importance of brain activity patterns that lack natural scales of sizes, durations, or frequencies. The field has developed prominent, and sometimes competing, explanations for the nature of this scale-free activity. Here, we reconcile these explanations across species and modalities. First, we link estimates of excitation-inhibition (E-I) balance with time-resolved correlation of distributed brain activity. Second, we develop an unbiased method for sampling time series constrained by this time-resolved correlation. Third, we use this method to show that estimates of E-I balance account for diverse scale-free phenomena without need to attribute additional function or importance to these phenomena. Collectively, our results simplify existing explanations of scale-free brain activity and provide stringent tests on future theories that seek to transcend these explanations.

Indexed as

NeurosciencesBrainTime Factors1/fcalcium imagingCP: Neuroscienceelectrophysiologyexcitation-inhibition balancescale-free brain activitytime-resolved correlation

Identifiers

PMID36966391
PMCPMC10518034

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.