ArticleDiabetology & metabolic syndrome2023
Association of prognostic nutritional index level and diabetes status with the prognosis of coronary artery disease: a cohort study.
Article in Diabetology & metabolic syndrome, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed.
- Article
- Prognostic nutritional index and long-term outcomes after coronary artery bypass grafting.BMC surgery · 2026Article
- Article
- The diagnostic value of prognostic nutritional ındex and controlling nutritional status score in differentiating retinal vein occlusion.International ophthalmology · 2026Article
- Article
- Article
- Role of Nutritional Status in Acute Coronary Syndrome Patients with Diabetes.Medicina (Kaunas, Lithuania) · 2025Article
- Impact of geriatric nutritional risk index and diabetes mellitus on prognosis in ischaemic heart failure with reduced ejection fraction.Scientific reports · 2025Article
- Prognostic nutritional index predicts staging and mortality in cardiovascular-kidney-metabolic syndrome.PloS one · 2025Article
- The relationship between the Geriatric Nutritional Risk Index and all-cause mortality in patients with peripheral artery disease.PloS one · 2025Article
- Implications of prognostic nutritional index in predicting adverse outcomes of uncontrolled diabetic patients: a cohort study of the national health and nutrition examination survey from 2005 - 2018.Diabetology & metabolic syndrome · 2024Article
- Evaluating the Prognostic Nutritional Index for Predicting the Clinical Relevance of Angiographically Intermediate Coronary Lesions.Anatolian journal of cardiology · 2024Article
- The effect of prognostic nutritional index on diabetic patients with myocardial infarction.Diabetology & metabolic syndrome · 2024Article
- Combination of the glycated hemoglobin levels and prognostic nutritional index as a prognostic marker in patients with acute coronary syndrome and type 2 diabetes mellitus.Lipids in health and disease · 2024Article
- Transcriptional profiles associated with coronary artery disease in type 2 diabetes mellitus.Frontiers in endocrinology · 2024Article
- A new parameter in predicting contrast-induced nephropathy: Osaka prognostic score.Revista da Associacao Medica Brasileira (1992) · 2024Article
- Association of prognostic nutritional index with the risk of all-cause mortality and cardiovascular mortality in patients with type 2 diabetes: NHANES 1999-2018.BMJ open diabetes research & care · 2023Article
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Abstract
backgroundMalnutrition and inflammation are associated with adverse clinical outcomes in patients with diabetes or coronary artery disease (CAD). Prognostic nutritional index (PNI) is a comprehensive and simple indicator reflecting nutritional condition and immunological status. Whether there is a crosstalk between nutritional-immunological status and diabetes status for the impact on the prognosis of coronary artery disease (CAD) is unclear.
methodsA total of 9429 consecutive CAD patients undergoing percutaneous coronary intervention were grouped by diabetes status [diabetes (DM) and non-diabetes (non-DM)] and preprocedural PNI level [high PNI (H-PNI) and low PNI (L-PNI)] categorized by the statistically optimal cut-off value of 48.49. The primary endpoint was all-cause death.
resultsDuring a median follow-up of 5.1 years (interquartile range: 5.0-5.1 years), 366 patients died. Compared with the non-DM/H-PNI group, the DM/L-PNI group yielded the highest risk of all-cause death (adjusted hazard ratio: 2.65, 95% confidence interval: 1.97-3.56, p < 0.001), followed by the non-DM/L-PNI group (adjusted hazard ratio: 1.44, 95% confidence interval: 1.05-1.98, p = 0.026), while DM/H-PNI was not associated with the risk of all-cause death. The negative effect of L-PNI on all-cause death was significantly stronger in diabetic patients than in nondiabetic patients (p for interaction = 0.037). Preprocedural PNI category significantly improved the Global Registry of Acute Coronary Events (GRACE) risk score for predicting all-cause death in patients with acute coronary syndrome, especially in those with diabetes.
conclusionsCAD patients with diabetes and L-PNI experienced the worst prognosis. The presence of diabetes amplifies the negative effect of L-PNI on all-cause death. Poor nutritional-immunological status outweighs diabetes in increasing the risk of all-cause death in CAD patients. Preprocedural PNI can serve as an assessment tool for nutritional and inflammatory risk and an independent prognostic factor in CAD patients, especially in those with diabetes.
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