Evidence map›Paper›PMID 36966271›Full record

ArticleBreast cancer research and treatment2023

Contrast enhanced mammography in breast cancer surveillance.

Kenneth Elder, Julia Matheson, Carolyn Nickson, Georgia Box, Jennifer Ellis, Arlene Mou, Clair Shadbolt, Allan Park, Jia Tay, Allison Rose and 1 more

Open access · hybridAbstract read
In one paragraph

Article in Breast cancer research and treatment, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
7.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. The Canadian Breast Cancer Symposium 2025: Meeting Report.Current oncology (Toronto, Ont.) · 2025
    Article
  5. Article
  6. Review
  7. Article
  8. Breast MRI to Screen Women With Extremely Dense Breasts.Journal of magnetic resonance imaging : JMRI · 2025
    Review
  9. Article
  10. Article
  11. Article
  12. Imaging in Interventional Radiology: Breast Cryoablation.Seminars in interventional radiology · 2025
    Review
  13. Contrast-enhanced mammography improves patient access to functional breast imaging.Journal of medical imaging and radiation oncology · 2025
    Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. State-of-the-art for contrast-enhanced mammography.The British journal of radiology · 2024
    Review
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Kenneth ElderThe Royal Melbourne Hospital, Grattan Street, Parkville, Melbourne, 3101, Australia. Kenneth.elder@nhslothian.scot.nhs.uk.ORCID http://orcid.org/0000-0001-6774-1717
Julia MathesonThe Royal Melbourne Hospital, Grattan Street, Parkville, Melbourne, 3101, Australia.
Carolyn NicksonDaffodil Centre, The University of Sydney, a joint venture with Cancer Council New South Wales, Sydney, Australia.
Georgia BoxThe Royal Melbourne Hospital, Grattan Street, Parkville, Melbourne, 3101, Australia.
Jennifer EllisThe Royal Melbourne Hospital, Grattan Street, Parkville, Melbourne, 3101, Australia.
Arlene MouThe Royal Women's Hospital, Flemington Road, Parkville, Melbourne, Australia.
Clair ShadboltThe Royal Women's Hospital, Flemington Road, Parkville, Melbourne, Australia.
Allan ParkThe Royal Women's Hospital, Flemington Road, Parkville, Melbourne, Australia.
Jia TayThe Royal Melbourne Hospital, Grattan Street, Parkville, Melbourne, 3101, Australia.
Allison RoseThe Royal Women's Hospital, Flemington Road, Parkville, Melbourne, Australia.
Gregory Bruce MannThe Royal Melbourne Hospital, Grattan Street, Parkville, Melbourne, 3101, Australia.
The Royal Melbourne Hospital · AURoyal Women's Hospital · AUThe University of Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeMammography (MG) is the standard imaging in surveillance of women with a personal history of breast cancer or DCIS (PHBC), supplemented with ultrasound. Contrast Enhanced Mammography (CEM) has higher sensitivity than MG and US. We report the performance of CEM compared with MG ± US.

methodsA retrospective study of patients undergoing their first surveillance CEM in an Australian hospital setting between June 2006 and October 2020. Cases where a patient was recalled for assessment were identified, recording radiology, pathology and treatment details. Blinded re-reading of recalled cases was performed to determine the contribution of contrast. Use of surveillance US across the board was assessed for the period.

results73/1191 (6.1%) patients were recalled. 35 (48%) were true positives (TP), with 26 invasive cancers and 9 cases of DCIS, while 38 (52%) were false positive (FP) with a positive predictive value (PPV) 47.9%. 32/73 were recalled due to MG findings, while 41/73 were only recalled due to Contrast. 14/73 had 'minimal signs' with a lesion identifiable on MG with knowledge of the contrast finding, while 27/73 were visible only with contrast. 41% (17/41) recalled due to contrast were TP. Contrast-only TPs were found with low and high mammographic density (MD). Screening breast US reduced by 55% in the year after CEM was implemented.

conclusionCompared to MG, CEM as a single surveillance modality for those with PHBC has higher sensitivity and comparable specificity, identifying additional malignant lesions that are clinically significant. Investigation of interval cancer and subsequent round outcomes is warranted.

Indexed as

Breast NeoplasmsCarcinoma, Intraductal, NoninfiltratingAustraliaBreastContrast MediaEarly Detection of CancerFemaleHumansMammographyRetrospective StudiesSensitivity and SpecificityContrast MediaBreast cancerCEMContrastMammographySurveillance

Identifiers

PMID36966271
PMCPMC10175447
OpenAlexW4360946214

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.