Evidence map›Paper›PMID 36966247›Full record

ArticleAnnals of biomedical engineering2023

Ex Vivo Modeling of Atrioventricular Valve Mechanics in Single Ventricle Physiology.

Stephen C Moye, Sumanth Kidambi, James Y Lee, Teaghan H Cowles, Shane D Gilligan-Steinberg, Amelia Y Bryan, Rob Wilkerson, Y Joseph Woo, Michael R Ma

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of biomedical engineering, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 95% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Stephen C MoyeDepartment of Cardiothoracic Surgery, Stanford University, 870 Quarry Rd, Stanford, CA, 94304, USA.
Sumanth KidambiDepartment of Cardiothoracic Surgery, Stanford University, 870 Quarry Rd, Stanford, CA, 94304, USA.
James Y LeeDepartment of Cardiothoracic Surgery, Stanford University, 870 Quarry Rd, Stanford, CA, 94304, USA.
Teaghan H CowlesDepartment of Cardiothoracic Surgery, Stanford University, 870 Quarry Rd, Stanford, CA, 94304, USA.
Shane D Gilligan-SteinbergDepartment of Cardiothoracic Surgery, Stanford University, 870 Quarry Rd, Stanford, CA, 94304, USA.
Amelia Y BryanDepartment of Cardiothoracic Surgery, Stanford University, 870 Quarry Rd, Stanford, CA, 94304, USA.
Rob WilkersonDepartment of Cardiothoracic Surgery, Stanford University, 870 Quarry Rd, Stanford, CA, 94304, USA.
Y Joseph WooDepartment of Cardiothoracic Surgery, Stanford University, 870 Quarry Rd, Stanford, CA, 94304, USA.
Michael R MaDepartment of Cardiothoracic Surgery, Stanford University, 870 Quarry Rd, Stanford, CA, 94304, USA. mma@stanford.edu.
Stanford University · US

Funding

Institutional Career Development Core (KL2)KL2TR003143 · NCATS · STANFORD UNIVERSITY · PI ASCH, STEVEN M. · 2019 to 2023
$8.7M
ANGIOGENIC TISSUE ENGINEERING TO LIMIT POST-INFARCTION VENTRICULAR REMODELINGR01HL089315 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI WOO, Y JOSEPH · 2008 to 2023
$6.4M
NCATS NIH HHS KL2 TR003143NCATS NIH HHS KL2TR003143NHLBI NIH HHS R01 HL089315
6 · The paper itself

Abstract

Single ventricle physiology (SVP) is used to describe any congenital heart lesion that is unable to support independent pulmonary and systemic circulations. Current treatment strategies rely on a series of palliation surgeries that culminate in the Fontan physiology, which relies on the single functioning ventricle to provide systemic circulation while passively routing venous return through the pulmonary circulation. Despite significant reductions in early mortality, the presence of atrioventricular valve (AVV) regurgitation is a key predictor of heart failure in these patients. We sought to evaluate the biomechanical changes associated with the AVV in SVP physiologies. Left and right ventricles were sutured onto patient-derived 3D-printed mounts and mounted into an ex vivo systemic heart simulator capable of reproducing Norwood, Glenn, Fontan and Late Fontan physiologies. We found that the tricuspid anterior leaflet experienced elevated maximum force, average force, and maximum yank compared to the posterior and septal leaflets. Between physiologies, maximum yank was greatest in the Norwood physiology relative to the Glenn, Fontan, and Late Fontan physiologies. These contrasting trends suggest that long- and short-term mechanics of AVV failure in single ventricle differ and that AVV interventions should account for asymmetries in force profiles between leaflets and physiologies.

Indexed as

Fontan ProcedureHeart Defects, CongenitalHeart ValvesHeart VentriclesHumansRetrospective StudiesTreatment OutcomeBioengineeringCHDEx vivoHeartLeafletsSimulator

Identifiers

PMID36966247
PMCPMC11460979
OpenAlexW4360944144

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.