Evidence map›Paper›PMID 36966194›Full record

ArticleScientific reports2023

Synthesis and biological evaluation of substituted acetamide derivatives as potential butyrylcholinestrase inhibitors.

Dehong Yu, Can Yang, Yi Liu, Tao Lu, Lizi Li, Gang Chen, Zerong Liu, Yanfang Li

Open access · goldFull text read
In one paragraph

Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 13 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Dehong YuSchool of Chemical Engineering, Sichuan University, Chengdu, 610065, China.
Can YangSchool of Chemical Engineering, Sichuan University, Chengdu, 610065, China.
Yi LiuSchool of Chemical Engineering, Sichuan University, Chengdu, 610065, China.
Tao LuSchool of Chemical Engineering, Sichuan University, Chengdu, 610065, China.
Lizi LiSchool of Chemical Engineering, Sichuan University, Chengdu, 610065, China.
Gang ChenCentral Nervous System Drug Key Laboratory of Sichuan Province, Luzhou, 646106, China.
Zerong LiuCentral Nervous System Drug Key Laboratory of Sichuan Province, Luzhou, 646106, China.
Yanfang LiSchool of Chemical Engineering, Sichuan University, Chengdu, 610065, China. lyf471@vip.163.com.
Sichuan University · CNLuye Pharma (China) · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alzheimer's disease (AD) is the most common type of age-related dementia. Inhibition of butyrylcholinesterase (BChE) emerge as an effective therapeutic target for AD. A series of new substituted acetamide derivatives were designed, synthesized and evaluated for their ability to inhibit BChE. The bioassay results revealed that several compounds displayed attractive inhibition against BChE). Among them, compound 8c exhibited the highest BChE inhibition with IC

Indexed as

Alzheimer DiseaseButyrylcholinesteraseAcetamidesAcetylcholinesteraseAmidesCholinesterase InhibitorsHumansMolecular Docking SimulationMolecular StructureStructure-Activity RelationshipAcetamidesAcetylcholinesteraseAmidesButyrylcholinesteraseCholinesterase Inhibitors

Identifiers

PMID36966194
PMCPMC10039877
OpenAlexW4360948873

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read129
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.