Evidence map›Paper›PMID 36966180›Full record

ArticleScientific reports2023

A common variant rs2054564 in ADAMST17 is associated with susceptibility to lumbar spondylosis.

Yuki Taniguchi, Toru Akune, Nao Nishida, Go Omori, Kim Ha, Kazuko Ueno, Taku Saito, Takeshi Oichi, Asako Koike, Akihiko Mabuchi and 8 more

Open access · goldFull text read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 8 institutions in 2 countries.

Yuki TaniguchiDepartment of Orthopedics, The University of Tokyo Hospital, Hongo 7-3-1, Bunkyo-Ku, Tokyo, 113-8655, Japan. taniguchi-tky@umin.ac.jp.
Toru AkuneHospital, National Rehabilitation Center for Persons with Disabilities, Tokorozawa, Saitama, 359-0042, Japan.
Nao NishidaGenome Medical Science Project, National Center for Global Health and Medicine, Tokyo, 162-8655, Japan.
Go OmoriDepartment of Health and Sports, Faculty of Health and Science, Niigata University of Health and Welfare, Niigata, 950-3198, Japan.
Kim HaDivision of Rheumatology, Department of Internal Medicine, Hallym University Sacred Heart Hospital, Anyang, 18450, Korea.
Kazuko UenoGenome Medical Science Project, National Center for Global Health and Medicine, Tokyo, 162-8655, Japan.
Taku SaitoDepartment of Orthopedics, The University of Tokyo Hospital, Hongo 7-3-1, Bunkyo-Ku, Tokyo, 113-8655, Japan.
Takeshi OichiDepartment of Orthopedics, The University of Tokyo Hospital, Hongo 7-3-1, Bunkyo-Ku, Tokyo, 113-8655, Japan.
Asako KoikeHealthcare Business Division, Hitachi, Ltd., Tokyo, 105-6412, Japan.
Akihiko MabuchiDepartment of Human Genetics, Graduate School of Medicine, The University of Tokyo, Tokyo, 113-8654, Japan.
Hiroyuki OkaDepartment of Medical Research and Management for Musculoskeletal Pain, 22nd Century Medical & Research Center, Faculty of Medicine, The University of Tokyo, Tokyo, 113-8654, Japan.
Shigeyuki MurakiDepartment of Preventive Medicine for Locomotive Organ Disorders, 22nd Century Medical and Research Center, The University of Tokyo, Tokyo, 113-8654, Japan.
Yasushi OshimaDepartment of Orthopedics, The University of Tokyo Hospital, Hongo 7-3-1, Bunkyo-Ku, Tokyo, 113-8655, Japan.
Hiroshi KawaguchiOrthopaedics and Spine Department, Tokyo Neurological Center, Tokyo, 105-0001, Japan.
Kozo NakamuraDepartment of Orthopedics, Towa Hospital, Tokyo, 120-0003, Japan.
Katsushi TokunagaGenome Medical Science Project, National Center for Global Health and Medicine, Tokyo, 162-8655, Japan.
Sakae TanakaDepartment of Orthopedics, The University of Tokyo Hospital, Hongo 7-3-1, Bunkyo-Ku, Tokyo, 113-8655, Japan.
Noriko YoshimuraDepartment of Preventive Medicine for Locomotive Organ Disorders, 22nd Century Medical and Research Center, The University of Tokyo, Tokyo, 113-8654, Japan.
University of Tokyo Hospital · JPThe University of Tokyo · JPNational Center for Global Health and Medicine · JPHallym University Sacred Heart Hospital · KRHitachi (Japan) · JPNational Rehabilitation Center for Persons with Disabilities · JPNiigata University of Health and Welfare · JPTowa Pharmaceutical (Japan) · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The molecular pathophysiology underlying lumbar spondylosis development remains unclear. To identify genetic factors associated with lumbar spondylosis, we conducted a genome-wide association study using 83 severe lumbar spondylosis cases and 182 healthy controls and identified 65 candidate disease-associated single nucleotide polymorphisms (SNPs). Replication analysis in 510 case and 911 control subjects from five independent Japanese cohorts identified rs2054564, located in intron 7 of ADAMTS17, as a disease-associated SNP with a genome-wide significance threshold (P = 1.17 × 10

Indexed as

Intervertebral DiscOsteoarthritis, SpineSpondylosisADAMTS ProteinsFibrillin-1FibrillinsGenome-Wide Association StudyHumansMicrofibrilsADAMTS17 protein, humanADAMTS ProteinsFibrillin-1Fibrillins

Identifiers

PMID36966180
PMCPMC10039864
OpenAlexW4360939361

What OpenQuestion holds

Textfull text, public
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.