ArticleNature communications2023
Organic electrochemical transistors as on-site signal amplifiers for electrochemical aptamer-based sensing.
Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed, 113 citations in OpenAlex.
- Miniaturization of Aptasensors in Organic Electrochemical Transistors for Sensitivity Enhancement.Analytical chemistry · 2026Article
- Damage-Free Passivation of Ambipolar OECTs with Fluoropolymer Film for Enhanced Performance and Stability Toward Reliable Biosignal Processing.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Gate Metal-Driven Sensing and Memory Bifunctionality in Intrinsically Stretchable Organic Electrochemical Transistors for Soft Neuromorphic Systems.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Decoding non-faradaic signal transduction in organic electrochemical transistor based biosensors.Nature communications · 2026Article
- Time-Multiplexed Organic Electrochemical Transistor for Saliva-Based Rapid Detection of Viral Proteins.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Electrochemical Biosensing Strategies for Oral Health: From Engineered Interfaces to Advanced Transistor Architectures.Advanced healthcare materials · 2026Review
- Convergence of Soft Electronics and Artificial Intelligence: From Materials to Intelligent Systems.Nano-micro letters · 2026Review
- Hydrogel-Based Semiconductors: Principles, Types, and Emerging Applications.Gels (Basel, Switzerland) · 2026Review
- Photopatterning of organic mixed ionic electronic conductors for monolithic complementary inverter.iScience · 2026Article
- Ionic-Bionic Interfaces: Advancing Iontronic Strategies for Bioelectronic Sensing and Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Dopamine-Mediated Analog Control of Electrochromic Reactions Through Organic Electrochemical Transistor.Small science · 2026Article
- Organic Electrochemical Transistors in Tissue-Interfaced Bioelectronics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Materials challenges in solid-state sensors for continuous monitoring of ions in water.Beilstein journal of nanotechnology · 2026Review
- Reconfigurable In-Sensor Computing Memristor for Olfactory SNN and Reservoir Hybrid Neuromorphic Computing.Research (Washington, D.C.) · 2026Article
- Wide-Field Digital Surface-Enhanced Raman Scattering: Quantitative Single-Molecule Detection with High Sensitivity and Throughput.Chemical & biomedical imaging · 2025Article
- All-Aqueous Phase Segregation Integrated Electrochemical Aptamer Biosensor Enables Picomolar Detection of SARS-CoV-2 Spike Protein.Small (Weinheim an der Bergstrasse, Germany) · 2025Article
- Rolling circle transcription-based fluorescent aptasensor for highly sensitive and onsite detection of microcystin-LR.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2025Article
- Engineering DNA Origami Captors for TGFβ1 Sequestration to Enhance Tumor Immune Modulation and Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Addressing transconductance-bandwidth trade-off by three-dimensional electrolyte-surrounded organic electrochemical transistors.Science advances · 2025Article
- Designing the Future of Biosensing: Advances in Aptamer Discovery, Computational Modeling, and Diagnostic Applications.Biosensors · 2025Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Electrochemical aptamer-based sensors are typically deployed as individual, passive, surface-functionalized electrodes, but they exhibit limited sensitivity especially when the area of the electrode is reduced for miniaturization purposes. We demonstrate that organic electrochemical transistors (electrolyte gated transistors with volumetric gating) can serve as on-site amplifiers to improve the sensitivity of electrochemical aptamer-based sensors. By monolithically integrating an Au working/sensing electrode, on-chip Ag/AgCl reference electrode, and Poly(3,4-ethylenedioxythiophene)-poly(styrenesulfonate) counter electrode - also serving as the channel of an organic electrochemical transistor- we can simultaneously perform testing of organic electrochemical transistors and traditional electroanalytical measurement on electrochemical aptamer-based sensors including cyclic voltammetry and square-wave voltammetry. This device can directly amplify the current from the electrochemical aptamer-based sensor via the in-plane current modulation in the counter electrode/transistor channel. The integrated sensor can sense transforming growth factor beta 1 with 3 to 4 orders of magnitude enhancement in sensitivity compared to that in an electrochemical aptamer-based sensor (292 μA/dec vs. 85 nA/dec). This approach is believed to be universal, and can be applied to a wide range of tethered electrochemical reporter-based sensors to enhance sensitivity, aiding in sensor miniaturization and easing the burden on backend signal processing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.