Evidence map›Paper›PMID 36965573›Full record

ReviewPhysiology & behavior2023

Somatosensory innervation of adipose tissues.

Yu Wang, Li Ye

Abstract readReview
In one paragraph

Review in Physiology & behavior, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Review
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Yu WangDepartment of Neuroscience and Dorris Neuroscience Center, The Scripps Research Institute, La Jolla, CA 92037, USA.
Li YeDepartment of Neuroscience and Dorris Neuroscience Center, The Scripps Research Institute, La Jolla, CA 92037, USA; Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA. Electronic address: liye@scripps.edu.

Funding

The Role of Sensory Neurons Innervating Internal OrgansR01AT012051 · NCCIH · SCRIPPS RESEARCH INSTITUTE, THE · PI PATAPOUTIAN, ARDEM · 2022 to 2025
$2.9M
Neural Mechanisms of Energy Expenditure-Induced Compensatory Food IntakeR01DK134609 · NIDDK · SCRIPPS RESEARCH INSTITUTE, THE · PI Li Ye · 2023 to 2026
$2.8M
Modulating somatosensory network to target metabolic diseasesDP2DK128800 · NIDDK · SCRIPPS RESEARCH INSTITUTE, THE · PI YE, LI · 2020 to 2020
$2.7M
Brain-wide functional mapping of circuits controlling hedonic feeding in obesityK01DK114165 · NIDDK · STANFORD UNIVERSITY · PI YE, LI · 2017 to 2021
$825k
NCCIH NIH HHS R01 AT012051NIDDK NIH HHS DP2 DK128800NIDDK NIH HHS K01 DK114165NIDDK NIH HHS R01 DK134609
6 · The paper itself

Abstract

The increasing prevalence of obesity and type 2 diabetes has led to a greater interest in adipose tissue physiology. Adipose tissue is now understood as an organ with endocrine and thermogenic capacities in addition to its role in fat storage. It plays a critical role in systemic metabolism and energy regulation, and its activity is tightly regulated by the nervous system. Fat is now recognized to receive sympathetic innervation, which transmits information from the brain, as well as sensory innervation, which sends information into the brain. The role of sympathetic innervation in adipose tissue has been extensively studied. However, the extent and the functional significance of sensory innervation have long been unclear. Recent studies have started to reveal that sensory neurons robustly innervate adipose tissue and play an important role in regulating fat activity. This brief review will discuss both historical evidence and recent advances, as well as important remaining questions about the sensory innervation of adipose tissue.

Indexed as

Diabetes Mellitus, Type 2Adipose TissueHumansNeurons, AfferentObesitySympathetic Nervous System

Identifiers

PMID36965573
PMCPMC11537203

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.