Evidence map›Paper›PMID 36965479›Full record

ArticleCurrent biology : CB2023

Chronic sleep loss sensitizes Drosophila melanogaster to nitrogen stress.

Joseph L Bedont, Anna Kolesnik, Pavel Pivarshev, Dania Malik, Cynthia T Hsu, Aalim Weljie, Amita Sehgal

Open access · hybridAbstract read
In one paragraph

Article in Current biology : CB, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 23 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Energy Deficit Is a Key Driver of Sleep Homeostasis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  5. Article
  6. Review
  7. Article
  8. A carnitine transporter at the blood-brain barrier modulates sleep via glial lipid metabolism inProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  9. Review
  10. Cold-raising unmasks sleep disruption in amicroPublication biology · 2025
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Joseph L BedontChronobiology and Sleep Institute, Perelman School of Medicine, University of Pennsylvania, 3400 Civic Center Boulevard, Philadelphia, PA 19104, USA.
Anna KolesnikChronobiology and Sleep Institute, Perelman School of Medicine, University of Pennsylvania, 3400 Civic Center Boulevard, Philadelphia, PA 19104, USA.
Pavel PivarshevChronobiology and Sleep Institute, Perelman School of Medicine, University of Pennsylvania, 3400 Civic Center Boulevard, Philadelphia, PA 19104, USA.
Dania MalikChronobiology and Sleep Institute, Perelman School of Medicine, University of Pennsylvania, 3400 Civic Center Boulevard, Philadelphia, PA 19104, USA.
Cynthia T HsuChronobiology and Sleep Institute, Perelman School of Medicine, University of Pennsylvania, 3400 Civic Center Boulevard, Philadelphia, PA 19104, USA.
Aalim WeljieChronobiology and Sleep Institute, Perelman School of Medicine, University of Pennsylvania, 3400 Civic Center Boulevard, Philadelphia, PA 19104, USA.
Amita SehgalChronobiology and Sleep Institute, Perelman School of Medicine, University of Pennsylvania, 3400 Civic Center Boulevard, Philadelphia, PA 19104, USA; Howard Hughes Medical Institute, 4000 Jones Bridge Road, Chevy Chase, MD 20815, USA. Electronic address: amita@pennmedicine.upenn.edu.
University of Pennsylvania · USHoward Hughes Medical Institute · US

Funding

Translational Research Support CoreP30ES013508 · NIEHS · UNIVERSITY OF PENNSYLVANIA · PI Trevor M Penning · 2006 to 2026
$35.3M
Balance of sleep and circadian metabolic switches in DrosophilaR01DK120757 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI SEHGAL, AMITA, WELJIE, AALIM M · 2019 to 2022
$2.1M
Nitrogen metabolism in sleep homeostasis and pathologyK99NS118561 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI BEDONT, JOSEPH L · 2020 to 2021
$186k
Characterizing metabolomic links between sleep deprivation and Alzheimers diseaseF32AG056081 · NIA · UNIVERSITY OF PENNSYLVANIA · PI BEDONT, JOSEPH L · 2017 to 2019
$137k
Howard Hughes Medical InstituteNIA NIH HHS F32 AG056081NIDDK NIH HHS R01 DK120757NIEHS NIH HHS P30 ES013508NINDS NIH HHS K99 NS118561
6 · The paper itself

Abstract

Chronic sleep loss profoundly impacts metabolic health and shortens lifespan, but studies of the mechanisms involved have focused largely on acute sleep deprivation.

Indexed as

Drosophila melanogasterDrosophila ProteinsAnimalsDrosophilaPolyaminesSleepDrosophila ProteinsPolyaminesDrosophilaexcretionlifespanlipidmetabolismmitochondriapolyamineproteinputrescinesleep

Identifiers

PMID36965479
PMCPMC10133188
OpenAlexW4360845389

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.