ArticleClinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology2023
State-dependent interhemispheric inhibition reveals individual differences in motor behavior in chronic stroke.
Article in Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
What it found
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The trial behind it
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Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 13 citations in OpenAlex.
- TMS-Derived Neurophysiological Measures of Corticospinal Excitability, Intracortical Excitability, and Interhemispheric Interactions Associated With Post-Stroke Motor Recovery: A Systematic Review.The European journal of neuroscience · 2026Pooled it
- Does SLT combined with NIBS enhance naming recovery in post-stroke aphasia? A meta-analysis and systematic review.NeuroRehabilitation · 2024Pooled it
- Effects of baclofen and lorazepam on interhemispheric inhibition in humans.Experimental physiology · 2026Trial
- Post-task resting-state fMRI of walking-related neural activity in patients with stroke: immediate and delayed brain network dynamics.Annals of medicine · 2026Article
- Right hemisphere language network plasticity in aphasia.Brain : a journal of neurology · 2026Article
- Mirror Visual Feedback Selectively Attenuates Crossover Fatigue in Distal Upper Limb Musculature: A Randomized Controlled Crossover Investigation Comparing Children and Adults.Life (Basel, Switzerland) · 2026Article
- Functional Near-Infrared Spectroscopy Reveals Functional Rewiring between Macaque Motor Areas Following Postinfarction Recovery of Manual Dexterity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Closed-loop brain-computer interfaces for post-stroke sensorimotor loop restoration.Frontiers in neuroscience · 2026Review
- Investigating repetitive transcranial magnetic stimulation-induced interhemispheric changes in stroke: a transcranial magnetic stimulation and fNIRS study.Neurophotonics · 2026Article
- Research progress on the mechanisms and clinical applications of neuromodulation techniques for intervening in interhemispheric imbalance after stroke.Frontiers in neurology · 2026Review
- Modulation of interhemispheric inhibition and motor learning by different intensities of bilateral transcranial direct current stimulation in healthy adults.Scientific reports · 2025Article
- Right Hemisphere Language Network Plasticity in Aphasia.medRxiv : the preprint server for health sciences · 2025Article
- Experience-driven competition in neural reorganization after stroke.The Journal of physiology · 2025Review
- Constraint-Induced Movement Therapy Promotes Contralesional Red Nucleus Plasticity and Increases Bilateral Motor Cortex-to-Red Nucleus Projections After a Large-Area Stroke.Behavioural neurology · 2025Article
- Rethinking Remapping: Circuit Mechanisms of Recovery after Stroke.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveTo investigate state-dependent interhemispheric inhibition (IHI) in chronic stroke survivors compared to neurotypical older adult controls, and test whether abnormal IHI modulation was associated with upper extremity motor behavior.
methodsDual-coil transcranial magnetic stimulation (TMS) measured IHI bi-directionally, between non-lesioned and lesioned motor cortex (M1) in two activity states: (1) at rest and (2) during contralateral isometric hand muscle contraction. IHI was tested by delivering a conditioning stimulus 8-msec or 50-msec prior to a test stimulus over contralateral M1. Paretic motor behavior was assessed by clinical measures of impairment, strength, and dexterity, and mirroring activity in the non-paretic hand.
resultsStroke survivors demonstrated reduced IHI at rest, and less IHI modulation (active - rest) compared to controls. Individual differences in IHI modulation were related to motor behavior differences where greater IHI modulation was associated with greater motor impairment and more mirroring. In contrast, there were no relationships between IHI at rest and motor behavior.
conclusionsAbnormal state-dependent interhemispheric circuit activity may be more sensitive to post-stroke motor deficits than when assessed in a single motor state. SIGNIFICANCE: Characterizing state-dependent changes in neural circuitry may enhance models of stroke recovery and inform rehabilitation interventions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.