Evidence map›Paper›PMID 36965419›Full record

ArticleBiochemical and biophysical research communications2023

Structural basis of main proteases of HCoV-229E bound to inhibitor PF-07304814 and PF-07321332.

Yanru Zhou, Weiwei Wang, Pei Zeng, Jingwen Feng, Dongyang Li, Yue Jing, Jin Zhang, Xiushan Yin, Jian Li, Heyang Ye and 1 more

Open access · greenAbstract read
In one paragraph

Article in Biochemical and biophysical research communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Unveiling the Multifaceted Capabilities of EndophyticPharmaceuticals (Basel, Switzerland) · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Yanru ZhouCollege of Pharmaceutical Sciences, Gannan Medical University, Ganzhou, 341000, China.
Weiwei WangShanghai Advanced Research Institute, Chinese Academy of Sciences, Shanghai, 201204, China.
Pei ZengShenzhen Crystalo Biopharmaceutical Co, Ltd, Shenzhen, 518118, China; Jiangxi Jmerry Biopharmaceutical Co, Ltd, Ganzhou, 341000, China.
Jingwen FengApplied Biology Laboratory, Shenyang University of Chemical Technology, 110142, Shenyang, China.
Dongyang LiApplied Biology Laboratory, Shenyang University of Chemical Technology, 110142, Shenyang, China.
Yue JingApplied Biology Laboratory, Shenyang University of Chemical Technology, 110142, Shenyang, China.
Jin ZhangShenzhen Crystalo Biopharmaceutical Co, Ltd, Shenzhen, 518118, China.
Xiushan YinApplied Biology Laboratory, Shenyang University of Chemical Technology, 110142, Shenyang, China.
Jian LiCollege of Pharmaceutical Sciences, Gannan Medical University, Ganzhou, 341000, China.
Heyang YeCollege of Pharmaceutical Sciences, Gannan Medical University, Ganzhou, 341000, China. Electronic address: wxb_1997@126.com.
Qisheng WangShanghai Advanced Research Institute, Chinese Academy of Sciences, Shanghai, 201204, China; Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, 201800, China. Electronic address: wangqs@sari.ac.cn.
Shenyang University of Chemical Technology · CNGannan Medical University · CNChinese Academy of Sciences · CNJiangsu T-mab BioPharma (China) · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PF-07321332 and PF-07304814, inhibitors against SARS-CoV-2 developed by Pfizer, exhibit broad-spectrum inhibitory activity against the main protease (M

Indexed as

Coronavirus 229E, HumanCOVID-19HumansPeptide HydrolasesSARS-CoV-2Peptide HydrolasesHCoV-229EInhibitorMain proteasePF-07304814PF-07321332

Identifiers

PMID36965419
PMCPMC10020134
OpenAlexW4327748014

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.