Trial reportJournal of clinical hypertension (Greenwich, Conn.)2023
Reductions in systolic blood pressure achieved by hypertensives with three isometric training sessions per week are maintained with a single session per week.
Trial report in Journal of clinical hypertension (Greenwich, Conn.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- The Optimal Dosage of Isometric Handgrip Exercise for Blood Pressure Reduction: Systematic Review and Meta-Analysis.Journal of clinical hypertension (Greenwich, Conn.) · 2026Pooled it
- The effect of long-term isometric contraction training intervention on blood pressure normalization in prehypertensive individuals: a systematic review and meta-analysis.BMC cardiovascular disorders · 2026Pooled it
- Effects of isometric training based on the entire population on blood pressure regulation: systematic review and meta-analysis of randomized controlled trials.Frontiers in public health · 2026Pooled it
- Comparing the efficacy of different types of exercise therapy in patients with essential hypertension: a systematic review and network meta-analysis.Frontiers in cardiovascular medicine · 2025Pooled it
- Impact of body mass index on blood pressure and cardiovascular adaptation to isometric exercise training.European journal of applied physiology · 2026Trial
- Trial
- Reductions in systolic blood pressure achieved by hypertensives with three isometric training sessions per week are maintained with a single session per week.Journal of clinical hypertension (Greenwich, Conn.) · 2023Trial
- Haemodynamic adaptations to isometric handgrip versus isometric wall squat exercise training: a randomised crossover study.European journal of applied physiology · 2026Article
- Article
- The Role of Muscle Strength, Physical Activity, Perceived Stress, and Sleep Quality in Patients with Hypertension.Journal of functional morphology and kinesiology · 2026Article
- Acute blood pressure responses to plank and wall sit isometric exercise in adults.Journal of hypertension · 2026Article
- Implementation, integration, and institutionalization of a community-based strategy for hypertension control in Colombia: the RE-HOPE implementation study protocol.Frontiers in cardiovascular medicine · 2026Article
- Isometric exercise training and blood pressure control: exploring the dose-response to training frequency in a randomised controlled trial.BMJ open sport & exercise medicine · 2026Article
- Factors associated with uncontrolled hypertension in Santander, Colombia: baseline findings from the RE-HOPE study.Journal of human hypertension · 2026Article
- Efficacy and moderators of isometric resistance training (IRT) on resting blood pressure among patients with pre- to established hypertension: a multilevel meta-review and regression analysis.BMC sports science, medicine & rehabilitation · 2025Article
- Isometric Exercise Training and Arterial Hypertension: An Updated Review.Sports medicine (Auckland, N.Z.) · 2024Review
- Effects of a maintenance period on ambulatory blood pressure and morning blood pressure surge in young normotensives post isometric training.Frontiers in physiology · 2024Article
- Handgrip Strength Is Associated with Specific Aspects of Vascular Function in Individuals with Metabolic Syndrome.Biomedicines · 2023Article
- Knowledge on muscle strength among health professionals in Colombia: cross- sectional study.Revista CuidarteArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Isometric handgrip or (wall) squat exercise performed three times per week produces reductions in systolic blood pressure (SBP) in adults with hypertension. We aimed to compare these interventions and the potential to retain benefits with one exercise session per week. We compared blood pressure changes following handgrip and squat isometric training interventions with controls in a randomized controlled multicentre trial in 77 unmedicated hypertensive (SBP ≥ 130 mmHg) adults. Exercise sessions were performed in the workplace and consisted of four repetitions-three sessions per week for the first 12 weeks (phase 1), and one session per week for the subsequent 12 weeks (phase 2). Office blood pressure (BP) was measured at baseline, post-phase 1 and post-phase 2. Post-phase 1, mean reductions in SBP were significantly greater in handgrip (-11.2 mmHg, n = 28) and squat (-12.9 mmHg, n = 27) groups than in controls (-.4 mmHg; n = 22) but changes in DBP were not. There were no significant within-group changes during phase 2 but SBP was 3.8 mmHg lower in the wall squat than the handgrip group-a small magnitude but clinically important difference. While both interventions produced significant SBP reductions, the wall squat appears to be more effective in maintaining benefits with a minimal training dose. The low time investment to achieve and retain clinically significant SBP reductions-42 and 12 min, respectively-and minimal cost, particularly of the wall squat, make it a promising intervention for delivery in public health settings.
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