ArticleMedical physics2023
Beam angle optimization for proton therapy via group-sparsity based angle generation method.
Article in Medical physics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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23 citing papers in PubMed.
- Optimizing allocation of limited proton fractions via NTCP-optimized combined proton-photon radiotherapy.Physical and engineering sciences in medicine · 2026Article
- Deep learning-based dose prediction in proton beam therapy for hepatocellular carcinoma: comparison of network architectures and loss functions.Journal of radiation research · 2026Article
- Collimator position optimization for proton minibeam radiation therapy.Scientific reports · 2026Article
- Geometry-based framework for beam angle selection in proton therapy for lung cancer.Physics and imaging in radiation oncology · 2026Article
- Single-field-uniform-dose-per-fraction simultaneous dose and dose rate optimization (SFUDPF-SDDRO) method for proton FLASH therapy.Medical physics · 2026Article
- Collimator position optimization for proton minibeam radiation therapy.Research square · 2026Article
- Dose optimization with fully flexible vertex positioning for LATTICE radiotherapy.Medical physics · 2026Article
- Time-saving potential of daily online adaptive proton therapy for head and neck cancers by reducing number of beams.Physics and imaging in radiation oncology · 2025Article
- Article
- Development and experimental validation of an in-house treatment planning system with greedy energy layer optimization for fast IMPT.Medical physics · 2025Article
- Compressed radiotherapy treatment planning: A new paradigm for rapid and high-quality treatment planning optimization.Medical physics · 2025Article
- A fully flexible joint lattice position and dose optimization method for LATTICE therapy.ArXiv · 2025Article
- Article
- Direct minimization of normal-tissue toxicity via an NTCP-based IMPT planning method.Medical physics · 2025Article
- Proton ARC based LATTICE radiation therapy: feasibility study, energy layer optimization and LET optimization.Physics in medicine and biology · 2024Article
- TEAM: Triangular-mEsh Adaptive and Multiscale proton spot generation method.Medical physics · 2024Article
- Simultaneous dose and dose rate optimization via dose modifying factor modeling for FLASH effective dose.Medical physics · 2024Article
- Biological optimization for hybrid proton-photon radiotherapy.Physics in medicine and biology · 2024Article
- Lattice position optimization for LATTICE therapy.Medical physics · 2023Article
- An orthogonal matching pursuit optimization method for solving minimum-monitor-unit problems: Applications to proton IMPT, ARC and FLASH.Medical physics · 2023Article
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6 authors.
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Abstract
backgroundIn treatment planning, beam angle optimization (BAO) refers to the selection of a subset with a given number of beam angles from all available angles that provides the best plan quality. BAO is a NP-hard combinatorial problem. Although exhaustive search (ES) can exactly solve BAO by exploring all possible combinations, ES is very time-consuming and practically infeasible. PURPOSE: To the best of our knowledge, (1) no optimization method has been demonstrated that can provide the exact solution to BAO, and (2) no study has validated an optimization method for solving BAO by benchmarking with the optimal BAO solution (e.g., via ES), both of which will be addressed by this work.
methodsThis work considers BAO for proton therapy, for example, the selection of 2-4 beam angles for IMPT. The optimal BAO solution is obtained via ES and serves as the ground truth. A new BAO algorithm, namely angle generation (AG) method, is proposed, and demonstrated to provide nearly-exact solutions for BAO in reference to the ES solution. AG iteratively optimizes the angular set via group-sparsity (GS) regularization, until the planning objective does not decrease further.
resultsSince GS alone can also solve BAO, AG was validated and compared with GS for 2-angle brain, 3-angle lung, and 4-angle brain cases, in reference to the optimal BAO solutions obtained by ES: the AG solution had the rank (1/276, 1/2024, 4/10 626), while the GS solution had the rank (42/276, 279/2024, 4328/10 626).
conclusionsA new BAO algorithm called AG is proposed and shown to provide substantially improved accuracy for BAO from current methods with nearly-exact solutions to BAO, in reference to the ground truth of optimal BAO solution via ES.
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