Evidence map›Paper›PMID 36965074›Full record

ArticleSmall (Weinheim an der Bergstrasse, Germany)2023

Physicochemical Properties and Route of Systemic Delivery Control the In Vivo Dynamics and Breakdown of Radiolabeled Gold Nanostars.

Xiaona Wen, Luping Ou, Gabriel Cutshaw, Saji Uthaman, Yu-Chuan Ou, Tian Zhu, Sarah Szakas, Brandon Carney, Jacob Houghton, Alexander Gundlach-Graham and 3 more

Open access · hybridAbstract read
In one paragraph

Article in Small (Weinheim an der Bergstrasse, Germany), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.1field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

Xiaona WenDepartment of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN, 37235, USA.ORCID 0000-0003-0441-4393
Luping OuCenter for Soft Condensed Matter Physics and Interdisciplinary Research and School of Physical Science and Technology, Soochow University, Suzhou, 215006, China.
Gabriel CutshawNanovaccine Institute, Iowa State University, Ames, IA, 50012, USA.
Saji UthamanNanovaccine Institute, Iowa State University, Ames, IA, 50012, USA.
Yu-Chuan OuDepartment of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN, 37235, USA.
Tian ZhuDepartment of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN, 37235, USA.
Sarah SzakasDepartment of Chemistry, Iowa State University, Ames, IA, 50011, USA.
Brandon CarneyDepartment of Radiology, Stony Brook University, Stony Brook, New York, NY, 11794, USA.
Jacob HoughtonDepartment of Radiology, Stony Brook University, Stony Brook, New York, NY, 11794, USA.
Alexander Gundlach-GrahamDepartment of Chemistry, Iowa State University, Ames, IA, 50011, USA.
Marjan RafatDepartment of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN, 37235, USA.
Kai YangCenter for Soft Condensed Matter Physics and Interdisciplinary Research and School of Physical Science and Technology, Soochow University, Suzhou, 215006, China.
Rizia BardhanNanovaccine Institute, Iowa State University, Ames, IA, 50012, USA.ORCID 0000-0002-5854-652X
Iowa State University · USVanderbilt University · USSoochow University · CNStony Brook University · US

Funding

Postdoctoral Training in Biomedical MRI and MRST32EB001628 · NIBIB · VANDERBILT UNIVERSITY MEDICAL CENTER · PI John C Gore · 2003 to 2026
$7.0M
Developing Multimodal Multiplexed ImmunoPET-Raman Probes to Guide ImmunotherapiesR01EB029756 · NIBIB · IOWA STATE UNIVERSITY · PI BARDHAN, RIZIA · 2020 to 2024
$1.2M
Deconstructing the Tumor Microenvironment and its Role in MetastasisR00CA201304 · NCI · VANDERBILT UNIVERSITY · PI RAFAT, MARJAN · 2018 to 2020
$728k
NCI NIH HHS R00 CA201304NIBIB NIH HHS R01 EB029756NIBIB NIH HHS T32 EB001628
6 · The paper itself

Abstract

The in vivo dynamics of nanoparticles requires a mechanistic understanding of multiple factors. Here, for the first time, the surprising breakdown of functionalized gold nanostars (F-AuNSs) conjugated with antibodies and

Indexed as

Metal NanoparticlesNanoparticlesGoldTissue DistributionGoldexocytosisgold nanostarsin vivo breakdownlong-term biodistributionMartini coarse-grained simulationspositron emission tomography (PET)protein corona

Identifiers

PMID36965074
PMCPMC10518372
OpenAlexW4360953623

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.