ArticleAging clinical and experimental research2023
Association between multidimensional prognostic index (MPI) and infections in a population of older people affected by COVID-19.
Article in Aging clinical and experimental research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Association between clinical frailty and multidrug-resistant positive cultures in hospitalized older adults.Internal and emergency medicine · 2026Article
- Sex and the Multidimensional Prognostic Index in 3.5-year post-COVID-19 mortality among older adults: evidence of a time-varying effect.Internal and emergency medicine · 2026Article
- Revolving Door in Older Patients: An Observational Study of Risk Assessment of Rehospitalization Using the BRASS Scale.Diseases (Basel, Switzerland) · 2025Article
- The Importance of Multidimensional Frailty in Clinical Practice.Journal of clinical medicine · 2024Article
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Authors and funding
11 authors.
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Abstract
backgroundOnly limited studies analyzed a possible relationship between frailty and infections. Our aim was to investigate the possible association between higher multidimensional prognostic index (MPI) values, a tool for evaluating multidimensional frailty, and the prevalence of infectious diseases, including antibiotics' cost and the prevalence of MDR (multidrug resistance) pathogens.
methodsOlder patients, affected by COVID-19, were enrolled in the hospital of Palermo over four months.
results112 participants (mean age 77.6, 55.4% males) were included. After adjusting for potential confounders, frailer participants had a higher odds of any positivity to pathogens (prevalence: 61.5%, odds ratio = 15.56, p < 0.0001) compared to a prevalence of 8.6% in more robust, including MDR, and a higher costs in antibiotics.
conclusionsHigher MPI values, indicating frailer subjects, were associated with a higher prevalence of infections, particularly of MDR pathogens, and a consequent increase in antibiotics' cost.
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