Evidence map›Paper›PMID 36964867›Full record

SynthesisAging clinical and experimental research2023

Implications of frailty in acute ischemic stroke receiving endovascular treatment: systematic review and meta-analysis.

QiangJi Bao, XiaoDong Huang, XinTing Wu, ShuJun Chen, JinCai Yang, JingNi Zhang, Jing Li, MingFei Yang

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Aging clinical and experimental research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Geriatric Models of Surgical Care: A Scoping Review.Journal of advanced nursing · 2026
    Article
  3. Review
  4. Observational
  5. Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

QiangJi Bao *Department of Neurosurgery, Southwest Hospital, Third Military Medical University, Chongqing, China.
XiaoDong Huang *Department of Neurosurgery, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei, China.
XinTing Wu *Graduate School, Qinghai University, Xining, Qinghai, China.
ShuJun Chen *Graduate School, Qinghai University, Xining, Qinghai, China.
JinCai YangGraduate School, Qinghai University, Xining, Qinghai, China.
JingNi ZhangDepartment of Science and Education, Qinghai Provincial People's Hospital, Xining, Qinghai, China. zhangjingni1985@163.com.
Jing LiDepartment of Community Health Education, Institute for Health Education of Qinghai Province, Xining, 810000, Qinghai, China. 1043249788@qq.com.
MingFei YangDepartment of Neurosurgery, Qinghai Provincial People's Hospital, Xining, 810007, Qinghai, China. iloveyoucmu@163.com.
Qinghai University · CNQinghai Provincial Peoples Hospital · CNSouthwest Hospital · CNTaihe Hospital · CN

Funding

Health Commission of Qinghai Province (No. 2021-wjzd-01)
6 · The paper itself

Abstract

backgroundFrailty is a state of cumulative degeneration of bodily functions that is consistently associated with poor outcomes in older people following illness. Combined stroke intervention and frailty may yield additive and synergistic effects adults with stroke.

objectiveTo evaluate the safety and efficacy of endovascular therapy (EVT) in frail patients.

methodsWe conducted a systematic review of the relationship between debilitation and acute ischemic stroke (AIS) after EVT. Until August 2022, researchers have searched three databases (Pubmed, EMBASE and Cochrane). Random-effects meta-analysis, combined ratio (OR) and 95% confidence interval (95%CI) were used to assess efficacy values. The I

resultsWe ultimately included eight studies including 3662 non-overlapping participants. Four studies used the Clinical Frailty Scale (CFS), two studies used the Hospital Frailty Risk Score (HFRS), a study used frailty index and a study used the comprehensive geriatric assessment (CGA). Frailty prevalence: 35%; 95% CI, 0.27-0.43; low quality evidence, downgraded due to heterogeneity, bias. Random effects showed that poor functional outcome (5 studies, OR 1.956, 95% CI 1.256-3.048) and mortality (9 studies, OR 2.320, 95% CI 1.680-3.205) was significantly associated with frailty. In adjusted analyses, poor functional outcome (4 studies, OR

conclusionPre-stroke frailty is an important predictor of poor prognosis assessed by EVT and can be added to the classical predictors of stroke outcome. Routine assessment of pre-stroke frailty can help patients to make decisions about the efficacy of their choice of EVT.

Indexed as

Endovascular ProceduresFrailtyIschemic StrokeStrokeAgedHumansRisk FactorsTreatment OutcomeEndovascular treatmentFrailtyMeta-analysisOutcomeStroke

Identifiers

PMID36964867
OpenAlexW4360942076

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.