Evidence map›Paper›PMID 36964824›Full record

ArticleNeurochemical research2023

Mitochondrial Complex I Inhibition in Dopaminergic Neurons Causes Altered Protein Profile and Protein Oxidation: Implications for Parkinson's disease.

Yogeshachar Chithra, Gourav Dey, Vivek Ghose, Vivek Chandramohan, Niya Gowthami, V Vasudev, M M Srinivas Bharath

Abstract read
PubMed Publisher
In one paragraph

Article in Neurochemical research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. A study of the correlation between cognitive function and thyroid hormones in patients with Parkinson's disease.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Article
  3. Article
  4. Neuroprotective Effects of Huperzine B andAdvances in pharmacological and pharmaceutical sciences · 2026
    Article
  5. Article
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  7. Review
  8. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 1 country.

Yogeshachar ChithraDepartment of Bioscience, P.G. Center, Hemagangotri, University of Mysore, Hassan, Karnataka, 573220, India.
Gourav DeyInstitute of Bioinformatics, International Tech Park, Bangalore, 560066, India.
Vivek GhoseManipal Academy of Higher Education, Udupi, Karnataka, 576104, India.
Vivek ChandramohanDepartment of Biotechnology, Siddaganga Institute of Technology, Tumkur, Karnataka, 572103, India.
Niya GowthamiDepartment of Clinical Psychopharmacology and Neurotoxicology, National Institute of Mental Health and Neurosciences (NIMHANS), No. 2900, Hosur Road, Lakkasandra, Bangalore, 560029, India.
V VasudevDepartment of Bioscience, P.G. Center, Hemagangotri, University of Mysore, Hassan, Karnataka, 573220, India.
M M Srinivas BharathDepartment of Clinical Psychopharmacology and Neurotoxicology, National Institute of Mental Health and Neurosciences (NIMHANS), No. 2900, Hosur Road, Lakkasandra, Bangalore, 560029, India. bharath@nimhans.ac.in.
National Institute of Mental Health and Neurosciences · INUniversity of Mysore · INInstitute of Bioinformatics · INManipal Academy of Higher Education · INSiddaganga Institute of Technology

Funding

National Institute of Mental Health and Neurosciences Institutional funds
6 · The paper itself

Abstract

Mitochondrial dysfunction and oxidative stress are critical to neurodegeneration in Parkinson's disease (PD). Mitochondrial dysfunction in PD entails inhibition of the mitochondrial complex I (CI) in the dopaminergic neurons of substantia nigra. The events contributing to CI inhibition and downstream pathways are not completely elucidated. We conducted proteomic analysis in a dopaminergic neuronal cell line exposed individually to neurotoxic CI inhibitors: rotenone (Rot), paraquat (Pq) and 1-methyl-4-phenylpyridinium (MPP

Indexed as

Dopaminergic NeuronsParkinson Disease1-Methyl-4-phenylpyridiniumCell DeathElectron Transport Complex IHumansParaquatProteomicsRotenone1-Methyl-4-phenylpyridiniumElectron Transport Complex IParaquatRotenoneMass spectrometryMolecular dynamicsMPP+ (1-methyl-4-phenylpyridinium)ParaquatPost-translational ModificationsRotenoneTryptophan

Identifiers

PMID36964824
OpenAlexW4360942002

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.