ArticleMultiple sclerosis (Houndmills, Basingstoke, England)2023
Neurophysiological MEG markers of cognitive impairment and performance validity in multiple sclerosis.
Article in Multiple sclerosis (Houndmills, Basingstoke, England), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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Who cites it
4 citing papers in PubMed, 5 citations in OpenAlex.
- Functional Connectivity at Rest and During Cognitive Processing in Multiple Sclerosis: A Pilot Magnetoencephalography Study and Systematic Review.Brain sciences · 2026Article
- Preserved α2 oscillations underpin reserve-related resilience of semantic verbal fluency in multiple sclerosis.Frontiers in neuroscience · 2026Article
- Task-induced 1/f slope modulation as a paradigm-independent marker of cognitive control in multiple sclerosis.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Cognitive impairment in multiple sclerosis: from phenomenology to neurobiological mechanisms.Journal of neural transmission (Vienna, Austria : 1996) · 2024Review
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSuboptimal performance during neuropsychological testing frequently occurs in multiple sclerosis (MS), leading to unreliable cognitive outcomes. Neurophysiological alterations correlate with MS-related cognitive impairment, but studies have not yet considered performance validity.
objectivesTo investigate neurophysiological markers of cognitive impairment in MS, while explicitly addressing performance validity.
methodsMagnetoencephalography recordings, neuropsychological assessments, and performance validity testing were obtained from 90 MS outpatients with cognitive complaints. Spectral and resting-state functional connectivity (rsFC) properties were compared between cognitively impaired (CI), cognitively preserved (CP), and suboptimally performing (SUB) patients using regression models and permutation testing.
resultsCI had higher power in low-frequency bands and lower power in high bands compared to CP, indicating neuronal slowing. CI also showed lower beta power compared to SUB. Overall power spectra visually differed between CI and CP, and SUB showed overlap with both groups. CI had lower rsFC than CP and SUB patients. CP and SUB patients showed no differences.
conclusionNeuronal slowing and altered rsFC can be considered cognitive markers in MS. Patients who performed suboptimally showed resemblance with patients with and without cognitive impairments, and although their overall neurophysiological profile was more similar to patients without impairments, it suggests heterogeneity regarding their pathophysiology.
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