Evidence map›Paper›PMID 36964499›Full record

ArticleBMC bioinformatics2023

EnsInfer: a simple ensemble approach to network inference outperforms any single method.

Bingran Shen, Gloria Coruzzi, Dennis Shasha

Full text read
In one paragraph

Article in BMC bioinformatics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Bingran ShenDepartment of Computer Science, Courant Institute of Mathematical Sciences, New York University, 251 Mercer St, New York, 10012, USA.
Gloria CoruzziDepartment of Biology, Center for Genomics and Systems Biology, New York University, 12 Waverly Pl, New York, 10003, USA.
Dennis ShashaDepartment of Computer Science, Courant Institute of Mathematical Sciences, New York University, 251 Mercer St, New York, 10012, USA. shasha@courant.nyu.edu.

Funding

Hit-and-Run transcription: The impact of transient interactions in dynamic gene regulatory networks that mediate rapid nutrient signalingR01GM121753 · NIGMS · NEW YORK UNIVERSITY · PI CORUZZI, GLORIA, SHASHA, DENNIS ELLIOTT · 2020 to 2023
$1.7M
National Science Foundation MCB-1412232NIGMS NIH HHS R01 GM121753NIH HHS R01GM121753-01A1
6 · The paper itself

Abstract

This study evaluates both a variety of existing base causal inference methods and a variety of ensemble methods. We show that: (i) base network inference methods vary in their performance across different datasets, so a method that works poorly on one dataset may work well on another; (ii) a non-homogeneous ensemble method in the form of a Naive Bayes classifier leads overall to as good or better results than using the best single base method or any other ensemble method; (iii) for the best results, the ensemble method should integrate all methods that satisfy a statistical test of normality on training data. The resulting ensemble model EnsInfer easily integrates all kinds of RNA-seq data as well as new and existing inference methods. The paper categorizes and reviews state-of-the-art underlying methods, describes the EnsInfer ensemble approach in detail, and presents experimental results. The source code and data used will be made available to the community upon publication.

Indexed as

AlgorithmsSoftwareBayes TheoremRNA-SeqGene regulatory networksMachine learningNon homogeneous ensembleTranscriptional regulation

Identifiers

PMID36964499
PMCPMC10037858

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.