Evidence map›Paper›PMID 36964402›Full record

ArticleGeroScience2023

Centenarian clocks: epigenetic clocks for validating claims of exceptional longevity.

Eric Dec, James Clement, Kaiyang Cheng, George M Church, Michael B Fossel, David H Rehkopf, Luis Rosero-Bixby, Michael S Kobor, David Ts Lin, Ake T Lu and 15 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in GeroScience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
6.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 44 citations in OpenAlex.

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  15. Quantification of Epigenetic Aging in Public Health.Annual review of public health · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors at 17 institutions in 7 countries.

Eric DecDepartment of Pediatrics, Division of Genetics and Genomic Medicine, University of California, Irvine, USA. dr.eric.dec@gmail.com.
James ClementBetterhumans Inc., Gainesville, FL, USA.
Kaiyang ChengMedical Informatics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
George M ChurchDepartment of Genetics, Harvard Medical School, Boston, MA, USA.
Michael B FosselTelocyte LLC, Grand Rapids, USA.
David H RehkopfEpidemiology & Population Health and Medicine, School of Medicine, Stanford University, Stanford, CA, USA.
Luis Rosero-BixbyCentro Centroamericano de Población, Universidad de Costa Rica, San Pedro, Costa Rica.
Michael S KoborEdwin S.H. Leong Healthy Aging Program, Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, BC, Canada.
David Ts LinEdwin S.H. Leong Healthy Aging Program, Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, BC, Canada.
Ake T LuDept. of Human Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
Zhe FeiDept. of Biostatistics, Fielding School of Public Health, University of California Los Angeles, Los Angeles, CA, USA.
Wei GuoZymo Research Corp, Irvine, CA, USA.
Yap Ching ChewZymo Research Corp, Irvine, CA, USA.
Xiaojing YangZymo Research Corp, Irvine, CA, USA.
Sulistyo E Dwi PutraDepartment of Biology, Faculty of Biotechnology, University of Surabaya, Surabaya, 60293, Indonesia.
Alex P ReinerPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109, USA.
Adolfo CorreaMedicine and Population Health Science, University of Mississippi Medical Center, Jackson, USA.
Adrian VilaltaOutcomes Metrics LLC, San Diego, CA, USA.
Chiara PirazziniIRCCS Istituto Delle Scienze Neurologiche Di Bologna, Bologna, Italy.
Giuseppe PassarinoDepartment of Biology Ecology and Earth Science, University of Calabria, Rende, Italy.
Daniela MontiDepartment of Experimental and Clinical, Biomedical Sciences "Mario Serio" University of Florence, Florence, Italy.
Beatrice ArosioDepartment of Clinical Sciences and Community Health, University of Milan, Milan, Italy.
Paolo GaragnaniDepartment of Medical and Surgical Sciences, University of Bologna, 40126, Bologna, Italy.
Claudio FranceschiDepartment of Medical and Surgical Sciences, University of Bologna, 40126, Bologna, Italy.
Steve HorvathDept. of Human Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA. shorvath@mednet.ucla.edu.ORCID 0000-0002-4110-3589
University of California, Los Angeles · USUniversity of British Columbia · CAEndocyte (United States) · USFred Hutch Cancer Center · USHarvard University · USIstituto delle Scienze Neurologiche di Bologna · ITJackson Memorial Hospital · USKarolinska University Hospital · SEN. I. Lobachevsky State University of Nizhny Novgorod · RUStanford University · USUniversidad de Costa Rica · CRUniversity of Calabria · ITUniversity of California, Irvine · USUniversity of Ferrara · ITUniversity of Florence · ITUniversity of Milan · ITUniversity of Surabaya · ID

Funding

Program Development (Pilot)P30AG012839 · NIA · UNIVERSITY OF CALIFORNIA BERKELEY · PI RONALD D LEE · 1999 to 2026
$18.6M
Validation and optimization of epigenetic clocksU01AG060908 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI RITZ, BEATE R. · 2018 to 2022
$3.4M
Exceptional Aging Across the Life Span: Framingham StudyR01AG029451 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI MURABITO, JOANNE M · 2008 to 2011
$1.3M
NHLBI NIH HHS HHSN268201500001INHLBI NIH HHS HHSN268201600001CNHLBI NIH HHS HHSN268201600002CNHLBI NIH HHS HHSN268201600003CNHLBI NIH HHS HHSN268201600004CNHLBI NIH HHS HHSN268201600018CNHLBI NIH HHS HHSN268201800010INHLBI NIH HHS HHSN268201800011INHLBI NIH HHS HHSN268201800012INHLBI NIH HHS HHSN268201800014INHLBI NIH HHS HHSN268201800015INIA NIH HHS P30 AG012839NIA NIH HHS R01 AG029451NIA NIH HHS U01 AG060908NIMHD NIH HHS HHSN268201800013I
6 · The paper itself

Abstract

Claims surrounding exceptional longevity are sometimes disputed or dismissed for lack of credible evidence. Here, we present three DNA methylation-based age estimators (epigenetic clocks) for verifying age claims of centenarians. The three centenarian clocks were developed based on n = 7039 blood and saliva samples from individuals older than 40, including n = 184 samples from centenarians, 122 samples from semi-supercentenarians (aged 105 +), and 25 samples from supercentenarians (aged 110 +). The oldest individual was 115 years old. Our most accurate centenarian clock resulted from applying a neural network model to a training set composed of individuals older than 40. An epigenome-wide association study of age in different age groups revealed that age effects in young individuals (age < 40) are correlated (r = 0.55) with age effects in old individuals (age > 90). We present a chromatin state analysis of age effects in centenarians. The centenarian clocks are expected to be useful for validating claims surrounding exceptional old age.

Indexed as

CentenariansLongevityAged, 80 and overDNA MethylationEpigenesis, GeneticHumansCentenarian clocksEpigenetic clocksLongevity

Identifiers

PMID36964402
PMCPMC10400760
OpenAlexW4360942071

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.