ArticleScientific reports2023
Partner separation rescues pair bond-induced decreases in hypothalamic oxytocin neural densities.
Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 14 citations in OpenAlex.
- Neural Mechanisms of Social Homeostasis: Dynamic Range Plasticity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Review
- Sex differences in structural and receptor mRNA expression in the ventral anterior cingulate cortex and a potential role of perineuronal nets in monogamous pair bond establishment (Peromyscus californicus).Biology of sex differences · 2025Article
- Aging leads to sex-dependent effects on pair bonding and increased number of oxytocin-producing neurons in monogamous prairie voles.Hormones and behavior · 2024Article
- Egalitarian cooperation linked to central oxytocin levels in communal breeding house mice.Communications biology · 2024Article
- Pair bond quality influences social conditioned place preference expression, passive coping behavior, and central oxytocin receptor expression following partner loss in male prairie voles.Social neuroscience · 2024Article
- Prairie voles as a model for adaptive reward remodeling following loss of a bonded partner.Annals of the New York Academy of Sciences · 2024Review
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Studies in prairie voles (Microtus ochrogaster) have shown that although formation of the pair bond is accompanied by a suite of behavioral changes, a bond between two voles can dissolve and individuals can form new pair bonds with other conspecifics. However, the neural mechanisms underlying this behavioral flexibility have not been well-studied. Here we examine plasticity of nonapeptide, vasopressin (VP) and oxytocin (OT), neuronal populations in relation to bonding and the dissolution of bonds. Using adult male and female prairie voles, animals were either pair bonded, co-housed with a same-sex sibling, separated from their pair bond partner, or separated from their sibling. We examined neural densities of VP and OT cell groups and observed plasticity in the nonapeptide populations of the paraventricular nucleus of the hypothalamus (PVN). Voles that were pair bonded had fewer PVN OT neurons, suggesting that PVN OT neural densities decrease with pair bonding, but increase and return to a pre-pair bonded baseline after the dissolution of a pair bond. Our findings suggest that the PVN nonapeptide cell groups are particularly plastic in adulthood, providing a mechanism by which voles can exhibit context-appropriate behavior related to bond status.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.