Evidence map›Paper›PMID 36964207›Full record

ArticleScientific reports2023

New insights into the neuroprotective and beta-secretase1 inhibitor profiles of tirandamycin B isolated from a newly found Streptomyces composti sp. nov.

Thitikorn Duangupama, Jaturong Pratuangdejkul, Sumet Chongruchiroj, Pattama Pittayakhajonwut, Chakapong Intaraudom, Sarin Tadtong, Patcharawee Nunthanavanit, Weerasak Samee, Ya-Wen He, Somboon Tanasupawat and 1 more

Open access · goldFull text read
In one paragraph

Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. International journal of microbiology · 2026
    Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 2 countries.

Thitikorn DuangupamaDepartment of Biology, School of Science, King Mongkut's Institute of Technology Ladkrabang, Bangkok, 10520, Thailand.
Jaturong PratuangdejkulDepartment of Microbiology, Faculty of Pharmacy, Mahidol University, Phayathai, Bangkok, 10400, Thailand.
Sumet ChongruchirojDepartment of Microbiology, Faculty of Pharmacy, Mahidol University, Phayathai, Bangkok, 10400, Thailand.
Pattama PittayakhajonwutNational Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency (NSTDA), Thailand Science Park, Phaholyothin Road, Klong Luang, 12120, Pathum Thani, Thailand.
Chakapong IntaraudomNational Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency (NSTDA), Thailand Science Park, Phaholyothin Road, Klong Luang, 12120, Pathum Thani, Thailand.
Sarin TadtongDepartment of Pharmacognosy, Faculty of Pharmacy, Srinakharinwirot University, Nakhon Nayok, 26120, Thailand.
Patcharawee NunthanavanitDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Srinakharinwirot University, Nakhon Nayok, 26120, Thailand.
Weerasak SameeDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Srinakharinwirot University, Nakhon Nayok, 26120, Thailand.
Ya-Wen HeState Key Laboratory of Microbial Metabolism, School of Life Sciences & Biotechnology, Shanghai Jiao Tong University, Shanghai, 200240, People's Republic of China.
Somboon TanasupawatDepartment of Biochemistry and Microbiology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, 10330, Thailand.
Chitti ThawaiDepartment of Biology, School of Science, King Mongkut's Institute of Technology Ladkrabang, Bangkok, 10520, Thailand. chitti.th@kmitl.ac.th.
Srinakharinwirot University · THKing Mongkut's Institute of Technology Ladkrabang · THMahidol University · THChulalongkorn University · THNational Center for Genetic Engineering and Biotechnology · THNational Science and Technology Development Agency · THShanghai Jiao Tong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tirandamycin (TAM B) is a tetramic acid antibiotic discovered to be active on a screen designed to find compounds with neuroprotective activity. The producing strain, SBST2-5

Indexed as

Amyloid Precursor Protein SecretasesStreptomycesAmino AcidsAminoglycosidesAnimalsAspartic Acid EndopeptidasesBacterial Typing TechniquesChlorocebus aethiopsDNADNA, BacterialFatty AcidsMiceMolecular Docking SimulationNucleic Acid HybridizationPhylogenyRNA, Ribosomal, 16SAmino AcidsAminoglycosidesAmyloid Precursor Protein SecretasesAspartic Acid EndopeptidasesDNADNA, BacterialFatty AcidsRNA, Ribosomal, 16Stirandamycin B

Identifiers

PMID36964207
PMCPMC10038987
OpenAlexW4360854456

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read88
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.