SynthesisScientific reports2023
Meta-analysis of the normal diffusion tensor imaging values of the peripheral nerves in the upper limb.
Synthesis in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The trial behind it
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Who cites it
9 citing papers in PubMed, 10 citations in OpenAlex.
- Biophysical Diffusion MRI Models Better Identify White Matter Tracts in Edema.Tomography (Ann Arbor, Mich.) · 2026Article
- Quantitative study and prognostic value of diffusion tensor imaging for lumbar spinal stenosis.BMC medical imaging · 2026Article
- Localizing Nerve Injury, Defining Injury Severity, and Estimating Prognosis (Nerve SPACE 2025).Journal of hand surgery global online · 2026Article
- Diagnostic Dilemmas in Carpal Tunnel Syndrome and Cervical Spine Disorders: A Comprehensive Review.Diagnostics (Basel, Switzerland) · 2025Review
- Diffusion tensor imaging in peroneal neuropathy: a prospective, single-centre study.BMJ neurology open · 2025Article
- Outcome Prediction by Diffusion Tensor Imaging (DTI) in Patients with Traumatic Injuries of the Median Nerve.Neurology international · 2024Article
- Transforming medicine: artificial intelligence integration in the peripheral nervous system.Frontiers in neurology · 2024Review
- Updates in peripheral nerve surgery of the upper extremity: diagnosis and treatment options.Annals of translational medicine · 2023Review
- High-Field Diffusion Tensor Imaging of Median, Tibial, and Sural Nerves in Type 2 Diabetes With Morphometric Analysis.Journal of neuroimaging : official journal of the American Society of NeuroimagingArticle
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
Abstract
Peripheral neuropathy affects 1 in 10 adults over the age of 40 years. Given the absence of a reliable diagnostic test for peripheral neuropathy, there has been a surge of research into diffusion tensor imaging (DTI) because it characterises nerve microstructure and provides reproducible proxy measures of myelination, axon diameter, fibre density and organisation. Before researchers and clinicians can reliably use diffusion tensor imaging to assess the 'health' of the major nerves of the upper limb, we must understand the "normal" range of values and how they vary with experimental conditions. We searched PubMed, Embase, medRxiv and bioRxiv for studies which reported the findings of DTI of the upper limb in healthy adults. Four review authors independently triple extracted data. Using the meta suite of Stata 17, we estimated the normal fractional anisotropy (FA) and diffusivity (mean, MD; radial, RD; axial AD) values of the median, radial and ulnar nerve in the arm, elbow and forearm. Using meta-regression, we explored how DTI metrics varied with age and experimental conditions. We included 20 studies reporting data from 391 limbs, belonging to 346 adults (189 males and 154 females, ~ 1.2 M:1F) of mean age 34 years (median 31, range 20-80). In the arm, there was no difference in the FA (pooled mean 0.59 mm
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.