ArticleNature communications2023
Aiolos represses CD4
Open access · goldFull text read
In one paragraph
Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 23 citations in OpenAlex.
- Clinical and immunological effects of adding cyclophosphamide to pomalidomide-dexamethasone in relapsed-refractory multiple myeloma: The randomized MUKseven trial.British journal of haematology · 2026Trial
- Local and circulating cytotoxic CD4medRxiv : the preprint server for health sciences · 2026Article
- The MEK1/2-IRF4 axis fosters T follicular helper cell differentiationand antitumor humoral immune response.Journal of translational medicine · 2026Article
- Cytotoxic CD4Signal transduction and targeted therapy · 2026Review
- Aiolos restricts the generation of antigen-inexperienced, virtual memory CD8Nature communications · 2025Article
- SwitchTFI: identifying transcription factors driving cell differentiation.Genome biology · 2025Article
- Transcription factor BACH2 shapes tissue-resident memory T cell programs to promote HIV-1 persistence.Immunity · 2025Article
- Cytotoxic T Cells: Kill, Memorize, and Mask to Maintain Immune Homeostasis.International journal of molecular sciences · 2025Review
- Enhancing the potency of CAR-T cells against solid tumors through transcription factor engineering.JCI insight · 2025Review
- The neutrophil-to-lymphocyte ratio and the prevalence of cutaneous melanoma: a retrospective observational study of NHANES statistics spanning 1999 to 2018.Archives of dermatological research · 2025Observational
- Supercharging CAR-T cells through transcriptional and epigenetic armoring.Theranostics · 2025Review
- Aiolos promotes CXCR3 expression on Th1 cells via positive regulation of IFN-γ/STAT1 signaling.JCI insight · 2024Article
- PRMT5 Promotes T follicular helper Cell Differentiation and Germinal Center Responses during Influenza Virus Infection.Journal of immunology (Baltimore, Md. : 1950) · 2024Article
- Review
- Cytotoxic Programming of CD4+ T Cells Is Regulated by Opposing Actions of the Related Transcription Factors Eos and Aiolos.Journal of immunology (Baltimore, Md. : 1950) · 2024Article
- The transcription factor Aiolos restrains the activation of intestinal intraepithelial lymphocytes.Nature immunology · 2024Article
- IKAROS Family Transcription Factors in Lymphocyte Differentiation and Function.Advances in experimental medicine and biology · 2024Review
- Cytotoxic CD4 development requires CD4 effectors to concurrently recognize local antigen and encounter type I IFN-induced IL-15.Cell reports · 2023Article
- Eos Promotes TH2 Differentiation by Interacting with and Propagating the Activity of STAT5.Journal of immunology (Baltimore, Md. : 1950) · 2023Article
- Immune surveillance and humoral immune responses in kidney transplantation - A look back at T follicular helper cells.Frontiers in immunology · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
21 authors at 3 institutions in 1 country.
Kaitlin A Read *Department of Microbial Infection and Immunity, The Ohio State University College of Medicine and Wexner Medical Center, Columbus, OH, 43210, USA.
Devin M Jones *Department of Microbial Infection and Immunity, The Ohio State University College of Medicine and Wexner Medical Center, Columbus, OH, 43210, USA.
Srijana PokhrelDepartment of Microbial Infection and Immunity, The Ohio State University College of Medicine and Wexner Medical Center, Columbus, OH, 43210, USA.
Emily D S HalesDepartment of Microbial Infection and Immunity, The Ohio State University College of Medicine and Wexner Medical Center, Columbus, OH, 43210, USA.
Aditi VarkeyDepartment of Microbial Infection and Immunity, The Ohio State University College of Medicine and Wexner Medical Center, Columbus, OH, 43210, USA.
Jasmine A TuazonDepartment of Microbial Infection and Immunity, The Ohio State University College of Medicine and Wexner Medical Center, Columbus, OH, 43210, USA.
Caprice D EiseleBiomedical Sciences Graduate Program, Columbus, OH, 43210, USA.
Omar AbdouniDepartment of Microbial Infection and Immunity, The Ohio State University College of Medicine and Wexner Medical Center, Columbus, OH, 43210, USA.
Abbey SaadeyDepartment of Microbial Infection and Immunity, The Ohio State University College of Medicine and Wexner Medical Center, Columbus, OH, 43210, USA.
Melissa R LeonardDepartment of Microbial Infection and Immunity, The Ohio State University College of Medicine and Wexner Medical Center, Columbus, OH, 43210, USA.ORCID 0000-0002-1680-3620
Robert T WarrenDepartment of Microbial Infection and Immunity, The Ohio State University College of Medicine and Wexner Medical Center, Columbus, OH, 43210, USA.
Michael D PowellDepartment of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA, 30322, USA.
Jeremy M BossDepartment of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA, 30322, USA.
Emily A HemannDepartment of Microbial Infection and Immunity, The Ohio State University College of Medicine and Wexner Medical Center, Columbus, OH, 43210, USA.
Jacob S YountDepartment of Microbial Infection and Immunity, The Ohio State University College of Medicine and Wexner Medical Center, Columbus, OH, 43210, USA.
Gang XinDepartment of Microbial Infection and Immunity, The Ohio State University College of Medicine and Wexner Medical Center, Columbus, OH, 43210, USA.
Hazem E GhoneimDepartment of Microbial Infection and Immunity, The Ohio State University College of Medicine and Wexner Medical Center, Columbus, OH, 43210, USA.ORCID 0000-0002-9816-4286
Chan-Wang J LioDepartment of Microbial Infection and Immunity, The Ohio State University College of Medicine and Wexner Medical Center, Columbus, OH, 43210, USA.
Aharon G FreudDepartment of Pathology, The Ohio State University College of Medicine and Wexner Medical Center, Columbus, OH, 43210, USA.ORCID 0000-0001-6086-1521
Patrick L CollinsDepartment of Microbial Infection and Immunity, The Ohio State University College of Medicine and Wexner Medical Center, Columbus, OH, 43210, USA.ORCID 0000-0003-4550-4272
Kenneth J OestreichDepartment of Microbial Infection and Immunity, The Ohio State University College of Medicine and Wexner Medical Center, Columbus, OH, 43210, USA. Ken.Oestreich@osumc.edu.ORCID 0000-0002-3004-072X
The Ohio State University Wexner Medical Center · USEmory University · USOhio Department of Health · US
Funding
Translational Therapeutics Research Program (TT)P30CA016058 · NCI · OHIO STATE UNIVERSITY · PI Daniel G. Stover · 1985 to 2026
$132.3MPREDOCTORAL TRAINING PROGRAM IN GENETICST32GM008490 · NIGMS · EMORY UNIVERSITY · PI BOSS, JEREMY M. · 1993 to 2022
$8.0MRegulation of PD-1 gene expressionR01AI113021 · NIAID · EMORY UNIVERSITY · PI BOSS, JEREMY M. · 2014 to 2024
$4.7MElucidation of Human Natural Killer Cell DevelopmentR01CA208353 · NCI · OHIO STATE UNIVERSITY · PI AHARON G FREUD · 2017 to 2026
$4.0MIdentifying novel regulatory pathways underlying T helper 1 cell immune responsesR01AI134972 · NIAID · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI OESTREICH, KENNETH JOSEPH · 2018 to 2022
$1.9MInterdisciplinary Program in Microbe-Host BiologyT32AI165391 · NIAID · OHIO STATE UNIVERSITY · PI RAJENDAR K DEORA, Daniel J Wozniak · 2022 to 2026
$1.5MTET-mediated Epigenetic Regulation in the Development and Immunoevasion of B cell LymphomaK22CA241290 · NCI · OHIO STATE UNIVERSITY · PI LIO, JERRY CHAN-WANG · 2020 to 2022
$485kGene regulatory architecture of CD56 bright natural killer cellsR21AI156411 · NIAID · OHIO STATE UNIVERSITY · PI COLLINS, PATRICK LEONARD · 2021 to 2022
$433kRegulation of T helper cell differentiation by integrated STAT and Ikaros zinc finger transcription factor mechanismsR56AI127800 · NIAID · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI OESTREICH, KENNETH JOSEPH · 2017 to 2017
$263kMechanisms of human PD-1 gene regulation in T follicular helper cellsF32AI161857 · NIAID · EMORY UNIVERSITY · PI POWELL, MICHAEL DUANE · 2021 to 2023
$200kNCI NIH HHS K22 CA241290NCI NIH HHS L30 CA199447NCI NIH HHS P30 CA016058NCI NIH HHS R01 CA208353NIAID NIH HHS F32 AI161857NIAID NIH HHS R01 AI113021NIAID NIH HHS R01 AI134972NIAID NIH HHS R21 AI156411NIAID NIH HHS R56 AI127800NIAID NIH HHS T32 AI165391NIGMS NIH HHS T32 GM008490
Abstract
During intracellular infection, T follicular helper (T
Indexed as
T-Lymphocytes, Helper-InducerTranscription FactorsCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCell DifferentiationInterleukin-2Interleukin-2Transcription Factors
Identifiers
What OpenQuestion holds
Textfull text, public
LicenceCC BY
measurements read99
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.