Evidence map›Paper›PMID 36964032›Full record

ArticleSeminars in perinatology2023

Stem cell derived therapies to preserve and repair the developing intestine.

Fikir M Mesfin, Krishna Manohar, Chelsea E Hunter, W Christopher Shelley, John P Brokaw, Jianyun Liu, Minglin Ma, Troy A Markel

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Seminars in perinatology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Utilization of Stem Cells in Medicine: A Narrative Review.International journal of molecular sciences · 2025
    Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Fikir M MesfinDepartment of Surgery, Section of Pediatric Surgery, Indiana University School of Medicine, Indianapolis, IN.
Krishna ManoharDepartment of Surgery, Section of Pediatric Surgery, Indiana University School of Medicine, Indianapolis, IN.
Chelsea E HunterDepartment of Surgery, Section of Pediatric Surgery, Indiana University School of Medicine, Indianapolis, IN.
W Christopher ShelleyDepartment of Surgery, Section of Pediatric Surgery, Indiana University School of Medicine, Indianapolis, IN.
John P BrokawDepartment of Surgery, Section of Pediatric Surgery, Indiana University School of Medicine, Indianapolis, IN.
Jianyun LiuDepartment of Surgery, Section of Pediatric Surgery, Indiana University School of Medicine, Indianapolis, IN.
Minglin MaDepartment of Biological and Environmental Engineering, Cornell University, Ithaca, NY.
Troy A MarkelDepartment of Surgery, Section of Pediatric Surgery, Indiana University School of Medicine, Indianapolis, IN; Riley Hospital for Children at Indiana University Health, Indianapolis, IN. Electronic address: tmarkel@iupui.edu.
Indiana University – Purdue University Indianapolis · USIndiana University School of MedicineCornell University · US

Funding

Neonatal gut-on-a-chip platform for high content drug testing and precision medicineR01HD105301 · NICHD · WASHINGTON UNIVERSITY · PI GOOD, MISTY L, MAGNESS, SCOTT T · 2021 to 2024
$2.4M
NICHD NIH HHS R01 HD105301
6 · The paper itself

Abstract

Stem cell research and the use of stem cells in therapy have seen tremendous growth in the last two decades. Neonatal intestinal disorders such as necrotizing enterocolitis, Hirschsprung disease, and gastroschisis have high morbidity and mortality and limited treatment options with varying success rates. Stem cells have been used in several pre-clinical studies to address various neonatal disorders with promising results. Stem cell and patient population selection, timing of therapy, as well as safety and quality control are some of the challenges that must be addressed prior to the widespread clinical application of stem cells. Further research and technological advances such as the use of cell delivery technology can address these challenges and allow for continued progress towards clinical translation.

Indexed as

Enterocolitis, NecrotizingGastroschisisInfant, Newborn, DiseasesHumansInfant, NewbornIntestinesStem Cell TransplantationMesenchymal stem cellsNecrotizing enterocolitisNeonatal intestinal disordersStem cell therapy

Identifiers

PMID36964032
PMCPMC10133028
OpenAlexW4323981501

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.