Evidence map›Paper›PMID 36963841›Full record

ArticleNeurology2023

Intracerebral Correlates of Scalp EEG Ictal Discharges Based on Simultaneous Stereo-EEG Recordings.

Mickaël Ferrand, Cédric Baumann, Olivier Aron, Jean-Pierre Vignal, Jacques Jonas, Louise Tyvaert, Sophie Colnat-Coulbois, Laurent Koessler, Louis Maillard

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Article in Neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Mickaël FerrandFrom the Department of Neurology (M.F., O.A., J.-P.V., J.J., L.T., L.M.), and University Hospital of Nancy, Lorraine University; Department of Epidemiology and Clinical Evaluation (C.B.), INSERM CIC-EC CIE6, Lorraine University, Vandoeuvre; Neurosciences of Systems and Cognition Project (O.A., J.J., L.T., L.K., L.M.), BioSiS Department (Department Biologie, Signaux et Systèmes en Cancérologie et Neurosciences), Research Center for Automatic Control of Nancy (CRAN), Lorraine University, CNRS, UMR 7039, Vandoeuvre; and Department of Neurosurgery (S.C.-C.), University Hospital of Nancy, Lorraine University, Nancy, France.ORCID 0000-0001-8778-7843
Cédric BaumannFrom the Department of Neurology (M.F., O.A., J.-P.V., J.J., L.T., L.M.), and University Hospital of Nancy, Lorraine University; Department of Epidemiology and Clinical Evaluation (C.B.), INSERM CIC-EC CIE6, Lorraine University, Vandoeuvre; Neurosciences of Systems and Cognition Project (O.A., J.J., L.T., L.K., L.M.), BioSiS Department (Department Biologie, Signaux et Systèmes en Cancérologie et Neurosciences), Research Center for Automatic Control of Nancy (CRAN), Lorraine University, CNRS, UMR 7039, Vandoeuvre; and Department of Neurosurgery (S.C.-C.), University Hospital of Nancy, Lorraine University, Nancy, France.
Olivier AronFrom the Department of Neurology (M.F., O.A., J.-P.V., J.J., L.T., L.M.), and University Hospital of Nancy, Lorraine University; Department of Epidemiology and Clinical Evaluation (C.B.), INSERM CIC-EC CIE6, Lorraine University, Vandoeuvre; Neurosciences of Systems and Cognition Project (O.A., J.J., L.T., L.K., L.M.), BioSiS Department (Department Biologie, Signaux et Systèmes en Cancérologie et Neurosciences), Research Center for Automatic Control of Nancy (CRAN), Lorraine University, CNRS, UMR 7039, Vandoeuvre; and Department of Neurosurgery (S.C.-C.), University Hospital of Nancy, Lorraine University, Nancy, France.
Jean-Pierre VignalFrom the Department of Neurology (M.F., O.A., J.-P.V., J.J., L.T., L.M.), and University Hospital of Nancy, Lorraine University; Department of Epidemiology and Clinical Evaluation (C.B.), INSERM CIC-EC CIE6, Lorraine University, Vandoeuvre; Neurosciences of Systems and Cognition Project (O.A., J.J., L.T., L.K., L.M.), BioSiS Department (Department Biologie, Signaux et Systèmes en Cancérologie et Neurosciences), Research Center for Automatic Control of Nancy (CRAN), Lorraine University, CNRS, UMR 7039, Vandoeuvre; and Department of Neurosurgery (S.C.-C.), University Hospital of Nancy, Lorraine University, Nancy, France.
Jacques JonasFrom the Department of Neurology (M.F., O.A., J.-P.V., J.J., L.T., L.M.), and University Hospital of Nancy, Lorraine University; Department of Epidemiology and Clinical Evaluation (C.B.), INSERM CIC-EC CIE6, Lorraine University, Vandoeuvre; Neurosciences of Systems and Cognition Project (O.A., J.J., L.T., L.K., L.M.), BioSiS Department (Department Biologie, Signaux et Systèmes en Cancérologie et Neurosciences), Research Center for Automatic Control of Nancy (CRAN), Lorraine University, CNRS, UMR 7039, Vandoeuvre; and Department of Neurosurgery (S.C.-C.), University Hospital of Nancy, Lorraine University, Nancy, France.
Louise TyvaertFrom the Department of Neurology (M.F., O.A., J.-P.V., J.J., L.T., L.M.), and University Hospital of Nancy, Lorraine University; Department of Epidemiology and Clinical Evaluation (C.B.), INSERM CIC-EC CIE6, Lorraine University, Vandoeuvre; Neurosciences of Systems and Cognition Project (O.A., J.J., L.T., L.K., L.M.), BioSiS Department (Department Biologie, Signaux et Systèmes en Cancérologie et Neurosciences), Research Center for Automatic Control of Nancy (CRAN), Lorraine University, CNRS, UMR 7039, Vandoeuvre; and Department of Neurosurgery (S.C.-C.), University Hospital of Nancy, Lorraine University, Nancy, France.
Sophie Colnat-CoulboisFrom the Department of Neurology (M.F., O.A., J.-P.V., J.J., L.T., L.M.), and University Hospital of Nancy, Lorraine University; Department of Epidemiology and Clinical Evaluation (C.B.), INSERM CIC-EC CIE6, Lorraine University, Vandoeuvre; Neurosciences of Systems and Cognition Project (O.A., J.J., L.T., L.K., L.M.), BioSiS Department (Department Biologie, Signaux et Systèmes en Cancérologie et Neurosciences), Research Center for Automatic Control of Nancy (CRAN), Lorraine University, CNRS, UMR 7039, Vandoeuvre; and Department of Neurosurgery (S.C.-C.), University Hospital of Nancy, Lorraine University, Nancy, France.
Laurent KoesslerFrom the Department of Neurology (M.F., O.A., J.-P.V., J.J., L.T., L.M.), and University Hospital of Nancy, Lorraine University; Department of Epidemiology and Clinical Evaluation (C.B.), INSERM CIC-EC CIE6, Lorraine University, Vandoeuvre; Neurosciences of Systems and Cognition Project (O.A., J.J., L.T., L.K., L.M.), BioSiS Department (Department Biologie, Signaux et Systèmes en Cancérologie et Neurosciences), Research Center for Automatic Control of Nancy (CRAN), Lorraine University, CNRS, UMR 7039, Vandoeuvre; and Department of Neurosurgery (S.C.-C.), University Hospital of Nancy, Lorraine University, Nancy, France.
Louis MaillardFrom the Department of Neurology (M.F., O.A., J.-P.V., J.J., L.T., L.M.), and University Hospital of Nancy, Lorraine University; Department of Epidemiology and Clinical Evaluation (C.B.), INSERM CIC-EC CIE6, Lorraine University, Vandoeuvre; Neurosciences of Systems and Cognition Project (O.A., J.J., L.T., L.K., L.M.), BioSiS Department (Department Biologie, Signaux et Systèmes en Cancérologie et Neurosciences), Research Center for Automatic Control of Nancy (CRAN), Lorraine University, CNRS, UMR 7039, Vandoeuvre; and Department of Neurosurgery (S.C.-C.), University Hospital of Nancy, Lorraine University, Nancy, France. l.maillard@chru-nancy.fr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectivesIt remains unknown to what extent ictal scalp EEG can accurately predict the localization of the intracerebral seizure onset in presurgical evaluation of drug-resistant epilepsies. In this study, we aimed to define homogeneous ictal scalp EEG profiles (based on their first ictal abnormality) and assess their localizing value using simultaneously recorded scalp EEG and stereo-EEG.

methodsWe retrospectively included consecutive patients with drug-resistant focal epilepsy who had simultaneous stereo-EEG and scalp EEG recordings of at least 1 seizure in the epileptology unit in Nancy, France. We analyzed 1 seizure per patient and used hierarchical cluster analysis to group similar seizure profiles on scalp EEG and then performed a descriptive analysis of their intracerebral correlates.

resultsWe enrolled 129 patients in this study. The hierarchical cluster analysis showed 6 profiles on scalp EEG first modification. None were specific to a single intracerebral localization. The "normal EEG" and "blurred EEG" clusters (early muscle artifacts) comprised only 5 patients each and corresponded to no preferential intracerebral localization. The "temporal discharge" cluster (n = 46) was characterized by theta or delta discharges on ipsilateral anterior temporal scalp electrodes and corresponded to a preferential mesial temporal intracerebral localization. The "posterior discharge" cluster (n = 42) was characterized by posterior ipsilateral or contralateral rhythmic alpha discharges or slow waves on scalp and corresponded to a preferential temporal localization. However, this profile was the statistically most frequent scalp EEG correlate of occipital and parietal seizures. The "diffuse suppression" cluster (n = 9) was characterized by a bilateral and diffuse background activity suppression on scalp and corresponded to mesial, and particularly insulo-opercular, localization. Finally, the "frontal discharge" cluster (n = 22) was characterized by bilateral frontal rhythmic fast activity or preictal spike on scalp and corresponded to preferential ventrodorsal frontal intracerebral localizations. DISCUSSION: The hierarchical cluster analysis identified 6 seizure profiles regarding the first abnormality on scalp EEG. None of them were specific of a single intracerebral localization. Nevertheless, the strong relationships between the "temporal," "frontal," "diffuse suppression," and "posterior" profiles and intracerebral discharge localizations may contribute to hierarchize hypotheses derived from ictal scalp EEG analysis regarding intracerebral seizure onset.

Indexed as

Drug Resistant EpilepsyEpilepsy, Temporal LobeElectroencephalographyHumansPatient DischargeRetrospective StudiesScalpSeizures

Identifiers

PMID36963841
PMCPMC10186237

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