ArticleAmerican journal of ophthalmology2023
Motion-Tracking Brillouin Microscopy Evaluation of Normal, Keratoconic, and Post-Laser Vision Correction Corneas.
Article in American journal of ophthalmology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 41 citations in OpenAlex.
- Corneal biomechanical and tomographic outcomes following accelerated cross-linking in keratoconus: a focus on cone localization.Japanese journal of ophthalmology · 2026Article
- Motion-Tracking Brillouin Microscopy for Keratoconus Suspect Identification: Comparison With Multimodal Corneal Imaging.American journal of ophthalmology · 2026Article
- Quantitative assessment of the biomechanical properties of healthy human myopic corneas using Brillouin spectroscopy.BMC ophthalmology · 2026Article
- [Diagnostic innovations for the early detection and characterization of keratoconus].Die Ophthalmologie · 2026Review
- Roadmap on advances in visual and physiological optics.Journal of optics (2010) · 2025Review
- Nanoindentation under retrocorneal pressure to determine the biomechanical response of the human cornea to accelerated UVA crosslinking and riboflavin osmolarity ex vivo.Scientific reports · 2025Article
- Three-Dimensional Mechanical Characterization of Normal, Subclinical, and Keratoconic Corneas Using Motion Tracking Brillouin Microscopy.American journal of ophthalmology · 2025Article
- Application of the Brillouin Optical Scanning System in the Regional Corneal Biomechanical Evaluation of Keratoconus and Its Correlation with Corvis ST Parameters.Bioengineering (Basel, Switzerland) · 2025Article
- Epithelial Mapping Efficacy for Subclinical Keratoconus Identification.American journal of ophthalmology · 2025Article
- In Vivo Brillouin Analysis of Lens Nucleus and Cortex in Adult Myopic Eyes and Their Correlation With Accommodation.Investigative ophthalmology & visual science · 2025Article
- Comparing the Performance of Stress-Strain Index Versions 1 and 2 in Normal and Keratoconus Patients.Translational vision science & technology · 2025Article
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- A Brillouin microscopy analysis of the crystalline lenses of Chinese adults with myopia.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2024Article
- Review
- Macrophage mediated mesoscale brain mechanical homeostasis mechanically imaged via optical tweezers and Brillouin microscopybioRxiv : the preprint server for biology · 2024Article
- In vivo measurement of the biomechanical properties of human skin with motion-corrected Brillouin microscopy.Biomedical optics express · 2024Article
- Subclinical Keratoconus Detection and Characterization Using Motion-Tracking Brillouin Microscopy.Ophthalmology · 2024Article
- Simultaneous tensile and shear measurement of the human cornea in vivo using S0- and A0-wave optical coherence elastography.Acta biomaterialia · 2024Article
- Keratoconus: imaging modalities and management.Medical hypothesis, discovery & innovation ophthalmology journal · 2024Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
purposeTo characterize focal biomechanical differences between normal, keratoconic, and post-laser vision correction (LVC) corneas using motion-tracking Brillouin microscopy.
designProspective cross-sectional study.
methodsThirty eyes from 30 patients (10 normal controls [Controls], 10 post-LVC, and 10 stage I or II keratoconus [KC]) had Scheimpflug and motion-tracking Brillouin microscopy imaging using a custom-built device. Mean, maximum (max) and minimum (min) Brillouin shift, spatial standard deviation, and max-min values were compared. Min values were correlated with local Brillouin values at multiple Scheimpflug imaging locations.
resultsMean (P < .0003), min (P < .00001), spatial standard deviation (P < .01), and max-min (P < .001) were significantly different between the groups. In post hoc pairwise comparisons, the best differentiators for group comparisons were mean (P = .0004) and min (P = .000002) for Controls vs KC, min (P = .0022) and max-min (P = .002) for Controls vs LVC, and mean (P = .0037) and min (P = .0043) for LVC vs KC. Min (area under the receiver operating characteristic = 1.0) and mean (area under the receiver operating characteristic = 0.96) performed well in differentiating Control and KC eyes. Min values correlated best with Brillouin shift values at the thinnest corneal point (r
conclusionsMotion-tracking Brillouin microscopy effectively characterized focal corneal biomechanical alterations in LVC and KC and clearly differentiated these groups from Controls. Primary motion-tracking Brillouin metrics performed well in differentiating groups as compared with basic Scheimpflug metrics, in contrast to previous Brillouin studies, and identified focal changes after LVC where prior Brillouin studies did not.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.