Evidence map›Paper›PMID 36963297›Full record

ArticleThe Journal of surgical research2023

Skeletal Muscle Bioenergetics in Critical Limb Ischemia and Diabetes.

Victoria G Rontoyanni, Elizabeth Blears, Omar Nunez Lopez, John Ogunbileje, Tatiana Moro, Nisha Bhattarai, Amanda C Randolph, Christopher S Fry, Grant T Fankhauser, Zulfiqar F Cheema and 4 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of surgical research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Victoria G RontoyanniDepartment of Surgery, University of Texas Medical Branch, Galveston, Texas.
Elizabeth BlearsDepartment of Surgery, University of Texas Medical Branch, Galveston, Texas.
Omar Nunez LopezDepartment of Surgery, University of Texas Medical Branch, Galveston, Texas.
John OgunbilejeDepartment of Surgery, University of Texas Medical Branch, Galveston, Texas.
Tatiana MoroDepartment of Nutrition and Metabolism, University of Texas Medical Branch, Galveston, Texas.
Nisha BhattaraiDepartment of Surgery, University of Texas Medical Branch, Galveston, Texas; Division of Rehabilitation Sciences, University of Texas Medical Branch, Galveston, Texas.
Amanda C RandolphDepartment of Nutrition and Metabolism, University of Texas Medical Branch, Galveston, Texas.
Christopher S FryDepartment of Nutrition and Metabolism, University of Texas Medical Branch, Galveston, Texas; Department of Internal Medicine, University of Texas Medical Branch, Galveston, Texas.
Grant T FankhauserDepartment of Surgery, University of Texas Medical Branch, Galveston, Texas.
Zulfiqar F CheemaDepartment of Surgery, University of Texas Medical Branch, Galveston, Texas.
Andrew J MurtonDepartment of Surgery, University of Texas Medical Branch, Galveston, Texas.
Elena VolpiDepartment of Nutrition and Metabolism, University of Texas Medical Branch, Galveston, Texas; Department of Internal Medicine, University of Texas Medical Branch, Galveston, Texas.
Blake B RasmussenDepartment of Nutrition and Metabolism, University of Texas Medical Branch, Galveston, Texas; Department of Internal Medicine, University of Texas Medical Branch, Galveston, Texas.
Craig PorterDepartment of Surgery, University of Texas Medical Branch, Galveston, Texas; Department of Pediatrics, University of Arkansas for Medical Sciences & Arkansas Children's Research Institute, Little Rock, Arkansas. Electronic address: cporter@uams.edu.
The University of Texas Medical Branch at Galveston · USArkansas Children's Hospital · US

Funding

UTMB OAIC Research Education Component (REC)P30AG024832 · NIA · UNIVERSITY OF TEXAS MEDICAL BR GALVESTON · PI JAMES S. GOODWIN, MD, MELISSA M. MORROW · 2005 to 2026
$26.7M
UTMB Clinical and Translational Science AwardUL1TR000071 · NCATS · UNIVERSITY OF TEXAS MED BR GALVESTON · PI BRASIER, ALLAN R. · 2012 to 2014
$14.4M
POSTDOCTORAL TRAINING IN TRAUMA &BURNST32GM008256 · NIGMS · UNIVERSITY OF TEXAS MEDICAL BR GALVESTON · PI Celeste Campbell Finnerty, Oscar E. Suman-Vejas · 1990 to 2026
$4.0M
Nutritional and Contractile Regulation of Muscle GrowthR01AR049877 · NIAMS · UNIVERSITY OF TEXAS MEDICAL BR GALVESTON · PI RASMUSSEN, BLAKE B · 2004 to 2012
$3.3M
Effects of amino acids on regional lipid metabolismR01AG033761 · NIA · UNIVERSITY OF TEXAS MED BR GALVESTON · PI BORSHEIM, ELISABET · 2009 to 2013
$1.6M
Nutrient Sensing & Signaling in Aging MuscleR56AG051267 · NIA · UNIVERSITY OF TEXAS MED BR GALVESTON · PI RASMUSSEN, BLAKE B · 2015 to 2015
$468k
Advanced Glycation End-products, Exercise, and SarcopeniaF30AG058381 · NIA · UNIVERSITY OF TEXAS MED BR GALVESTON · PI RANDOLPH, AMANDA · 2017 to 2021
$187k
NCATS NIH HHS UL1 TR000071NIAMS NIH HHS R01 AR049877NIA NIH HHS F30 AG058381NIA NIH HHS P30 AG024832NIA NIH HHS R01 AG033761NIA NIH HHS R56 AG051267NIGMS NIH HHS T32 GM008256
6 · The paper itself

Abstract

introductionMitochondrial dysfunction is implicated in the metabolic myopathy accompanying peripheral artery disease (PAD) and critical limb ischemia (CLI). Type-2 diabetes mellitus (T2DM) is a major risk factor for PAD development and progression to CLI and may also independently be related to mitochondrial dysfunction. We set out to determine the effect of T2DM in the relationship between CLI and muscle mitochondrial respiratory capacity and coupling control.

methodsWe studied CLI patients undergoing revascularization procedures or amputation, and non-CLI patients with or without T2DM of similar age. Mitochondrial respiratory capacity and function were determined in lower limb permeabilized myofibers by high-resolution respirometry.

resultsFourteen CLI patients (65 ± 10y) were stratified into CLI patients with (n = 8) or without (n = 6) T2DM and were compared to non-CLI patients with (n = 18; 69 ± 5y) or without (n = 19; 71 ± 6y) T2DM. Presence of CLI but not T2DM had a marked impact on all mitochondrial respiratory states in skeletal muscle, adjusted for the effects of sex. Leak respiration (State 2, P < 0.025 and State 4

conclusionsSkeletal muscle mitochondrial respiratory capacity was blunted by ∼35% in patients with CLI. T2DM was not associated with muscle oxidative capacity and did not moderate the relationship between muscle mitochondrial respiratory capacity and CLI.

Indexed as

Diabetes MellitusPeripheral Arterial DiseaseAdultChronic Limb-Threatening IschemiaEnergy MetabolismHumansIschemiaLimb SalvageMuscle, SkeletalRisk FactorsTreatment OutcomeCritical limb ischemiaDiabetesMitochondriaOxidative phosphorylationPeripheral artery disease

Identifiers

PMID36963297
PMCPMC10192034
OpenAlexW4353034333

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.