ArticlePLOS global public health2022
Performance of highly sensitive and conventional rapid diagnostic tests for clinical and subclinical Plasmodium falciparum infections, and hrp2/3 deletion status in Burundi.
Article in PLOS global public health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 25 citations in OpenAlex.
- Diagnostic accuracy of novel Biocredit species-specific LDH-based immunochromatographic assay for Plasmodium falciparum and Plasmodium vivax detection: a systematic review and meta-analysis.BMC infectious diseases · 2026Pooled it
- A quantitative and systematic analysis of Anopheles stephensi bionomics and control approaches.Acta tropica · 2024Pooled it
- High-AltitudeOpen forum infectious diseases · 2026Article
- Evaluation of NxTek™ Eliminate Malaria-PF test and biocredit rapid diagnostic tests for detecting Plasmodium species in Southern Ethiopia.BMC infectious diseases · 2026Article
- First field evaluation of novel LDH- and HRP2-based rapid tests for Plasmodium vivax and Plasmodium falciparum malaria diagnosis.PLoS neglected tropical diseases · 2025Article
- Performance and usability evaluation of three LDH-based malaria rapid diagnostic tests in Kédougou, Senegal.Parasites & vectors · 2025Article
- A NovelmedRxiv : the preprint server for health sciences · 2025Article
- The burden and diagnostic challenges of subclinical Plasmodium falciparum infections in Southern Ghana.BMC infectious diseases · 2025Article
- Estimating malaria antigen dynamics and the time to negativity of next-generation malaria rapid diagnostic tests.Malaria journal · 2025Article
- Bridging the Gap from Molecular Surveillance to Programmatic Decisions for Malaria Control and Elimination.The American journal of tropical medicine and hygiene · 2025Review
- Article
- Performance and usability evaluation of three LDH-based malaria rapid diagnostic tests in Kédougou, Senegal.medRxiv : the preprint server for health sciences · 2024Article
- Analytical Sensitivity Analysis and Clinical Impact Modeling of Rapigen Rapid Diagnostic Tests for Malaria.The American journal of tropical medicine and hygiene · 2024Article
- Comparison of three rapid diagnostic tests for Plasmodium falciparum diagnosis in Ghana.Malaria journal · 2024Article
- High prevalence of asymptomatic and subpatent Plasmodium falciparum infections but no histidine-rich protein 2 gene deletion in Bouaké, Côte d'Ivoire.Scientific reports · 2024Article
- A digital microscope for the diagnosis of Plasmodium falciparum and Plasmodium vivax, including P. falciparum with hrp2/hrp3 deletion.PLOS global public health · 2024Article
- Is qPCR always the most sensitive method for malaria diagnostic quality surveillance?Malaria journal · 2023Article
- Article
- Altitude, not potential larval habitat availability, explains pronounced variation in Plasmodium falciparum infection prevalence in the western Kenya highlands.PLOS global public health · 2023Article
- Factors Affecting the Performance of HRP2-Based Malaria Rapid Diagnostic Tests.Tropical medicine and infectious disease · 2022Review
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Authors and funding
14 authors at 5 institutions in 5 countries.
Funding
Abstract
Rapid diagnostic tests (RDTs) are a key tool for the diagnosis of malaria infections among clinical and subclinical individuals. Low-density infections, and deletions of the P. falciparum hrp2/3 genes (encoding the HRP2 and HRP3 proteins detected by many RDTs) present challenges for RDT-based diagnosis. The novel Rapigen Biocredit three-band Plasmodium falciparum HRP2/LDH RDT was evaluated among 444 clinical and 468 subclinical individuals in a high transmission setting in Burundi. Results were compared to the AccessBio CareStart HRP2 RDT, and qPCR with a sensitivity of <0.3 parasites/μL blood. Sensitivity compared to qPCR among clinical patients for the Biocredit RDT was 79.9% (250/313, either of HRP2/LDH positive), compared to 73.2% (229/313) for CareStart (P = 0.048). Specificity of the Biocredit was 82.4% compared to 96.2% for CareStart. Among subclinical infections, sensitivity was 72.3% (162/224) compared to 58.5% (131/224) for CareStart (P = 0.003), and reached 88.3% (53/60) in children <15 years. Specificity was 84.4% for the Biocredit and 93.4% for the CareStart RDT. No (0/362) hrp2 and 2/366 hrp3 deletions were observed. In conclusion, the novel RDT showed improved sensitivity for the diagnosis of P. falciparum.
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Registered trials
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