Evidence map›Paper›PMID 36962424›Full record

ArticlePLOS global public health2022

Urban risk factors for human Rift Valley fever virus exposure in Kenya.

Keli Nicole Gerken, Francis Maluki Mutuku, Bryson Alberto Ndenga, Gladys Adhiambo Agola, Eleonora Migliore, Eduardo Palacios Fabre, Said Malumbo, Karren Nyumbile Shaita, Izabela Mauricio Rezende, A Desiree LaBeaud

Open access · goldFull text read
In one paragraph

Article in PLOS global public health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
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  9. Temporal Variation and Human Host Predominance inPathogens (Basel, Switzerland) · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Keli Nicole GerkenDepartment of Pediatrics, Division of Infectious Diseases, Stanford University School of Medicine, Stanford, California, United States of America.ORCID https://orcid.org/0000-0001-9337-2409
Francis Maluki MutukuDepartment of Environment and Health Sciences, Technical University of Mombasa, Mombasa, Kenya.ORCID https://orcid.org/0000-0002-9000-7008
Bryson Alberto NdengaCentre for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya.ORCID https://orcid.org/0000-0002-8445-2885
Gladys Adhiambo AgolaCentre for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya.ORCID https://orcid.org/0000-0001-7385-8719
Eleonora MiglioreDepartment of Pediatrics, Division of Infectious Diseases, Stanford University School of Medicine, Stanford, California, United States of America.ORCID https://orcid.org/0000-0001-7339-5267
Eduardo Palacios FabreDepartment of Pediatrics, Division of Infectious Diseases, Stanford University School of Medicine, Stanford, California, United States of America.ORCID https://orcid.org/0000-0003-2176-3317
Said MalumboVector Borne Disease Control Unit, Msambweni County Referral Hospital, Kwale, Kenya.
Karren Nyumbile ShaitaCentre for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya.ORCID https://orcid.org/0000-0002-2738-8231
Izabela Mauricio RezendeDepartment of Pediatrics, Division of Infectious Diseases, Stanford University School of Medicine, Stanford, California, United States of America.
A Desiree LaBeaudDepartment of Pediatrics, Division of Infectious Diseases, Stanford University School of Medicine, Stanford, California, United States of America.ORCID https://orcid.org/0000-0001-8364-6867
Stanford University · USKenya Medical Research Institute · KETechnical University of Mombasa · KE

Funding

Research Mentoring and Building Capacity of underrepresented Minority Research Scientists in India.D43TW010540 · FIC · YALE UNIVERSITY · PI MICHELE BARRY, Eva Harris · 2017 to 2026
$15.5M
The child health impacts of overlapping vector-borne diseases in KenyaR01AI102918 · NIAID · STANFORD UNIVERSITY · PI Angelle Desiree LaBeaud · 2013 to 2026
$7.7M
FIC NIH HHS D43 TW010540NIAID NIH HHS R01 AI102918
6 · The paper itself

Abstract

The Rift Valley fever virus (RVFV) is a zoonotic arbovirus that can also transmit directly to humans from livestock. Previous studies have shown consumption of sick animal products are risk factors for RVFV infection, but it is difficult to disentangle those risk factors from other livestock rearing activities. Urban areas have an increased demand for animal source foods, different vector distributions, and various arboviruses are understood to establish localized urban transmission cycles. Thus far, RVFV is an unevaluated public health risk in urban areas within endemic regions. We tested participants in our ongoing urban cohort study on dengue (DENV) and chikungunya (CHIKV) virus for RVFV exposure and found 1.6% (57/3,560) of individuals in two urban areas of Kenya had anti-RVFV IgG antibodies. 88% (50/57) of RVFV exposed participants also had antibodies to DENV, CHIKV, or both. Although livestock ownership was very low in urban study sites, RVFV exposure was overall significantly associated with seeing goats around the homestead (OR = 2.34 (CI 95%: 1.18-4.69, p = 0.02) and in Kisumu, RVFV exposure was associated with consumption of raw milk (OR = 6.28 (CI 95%: 0.94-25.21, p = 0.02). In addition, lack of piped water and use of small jugs (15-20 liters) for water was associated with a higher risk of RVFV exposure (OR = 5.36 (CI 95%: 1.23-16.44, p = 0.01) and this may contribute to interepidemic vector-borne maintenance of RVFV. We also investigated perception towards human vaccination for RVFV and identified high acceptance (91% (97/105) at our study sites. This study provides baseline evidence to guide future studies investigating the urban potential of RVFV and highlights the unexplored role of animal products in continued spread of RVFV.

Identifiers

PMID36962424
PMCPMC10021321
OpenAlexW4285388899

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read53
identifiers read10
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.