ArticlePLOS global public health2021
Economic impact of dengue in Singapore from 2010 to 2020 and the cost-effectiveness of Wolbachia interventions.
Article in PLOS global public health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The epidemiologic and economic burden of dengue in Singapore: A systematic review.PLoS neglected tropical diseases · 2024Pooled it
- Wolbachia-carrying Aedes mosquitoes for preventing dengue infection.The Cochrane database of systematic reviews · 2024Pooled it
- Adjacent spillover efficacy of Wolbachia for control of dengue: emulation of a cluster randomised target trial.BMC medicine · 2025Trial
- Assessing Wolbachia-mediated sterility for dengue control: emulation of a cluster-randomized target trial in Singapore.Journal of travel medicine · 2024Trial
- From bites to ripple effects: Unraveling the health, economic, and social effects of arboviral epidemics in Mainland France.IJID regions · 2026Article
- The cost-effectiveness of Wolbachia-based biocontrol interventions for dengue: A scoping review of the available evidence.PLoS neglected tropical diseases · 2026Article
- Combating dengue using maleThe Lancet regional health. Western Pacific · 2026Article
- Two Decades of Dengue in Indonesia: Long-Term Trends in Incidence, Mortality, and Disability-Adjusted Life Years, 2005-2024.Pathogens (Basel, Switzerland) · 2026Article
- Adult dengue vaccination in a low transmission setting: A modelling study in Singapore.PLoS neglected tropical diseases · 2026Article
- The impact of large-scale release ofLancet regional health. Americas · 2026Article
- ModellingJournal of pest science · 2026Article
- Diversity ofInsects · 2025Article
- "Basically a PR exercise…": a qualitative study of expert perspectives on 'performative versus evidence-informed' dengue vector control in the Asia-Pacific region.BMJ global health · 2025Article
- Influence of the physicochemical characteristics of mosquito breeding sites in domestic environments on the distributions of Anopheles, Aedes and Culex mosquitoes in Benin.Tropical medicine and health · 2025Article
- ExploitingPathogens (Basel, Switzerland) · 2025Review
- Article
- Wolbachia incompatible insect technique program optimization over large spatial scales using a process-based model of mosquito metapopulation dynamics.BMC biology · 2024Article
- Current status of the sterile insect technique for the suppression of mosquito populations on a global scale.Infectious diseases of poverty · 2024Review
- Transfusion of Blood Products and Clinical Outcomes for Patients With Dengue Fever: A Systematic Review and Meta-analysis.Open forum infectious diseases · 2024Review
- Simulation-based economic evaluation of the Wolbachia method in Brazil: a cost-effective strategy for dengue control.Lancet regional health. Americas · 2024Article
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The release of Wolbachia-infected mosquitoes is a promising disease intervention strategy that aims to control dengue and other arboviral infections. While early field trials and modelling studies suggest promising epidemiological and entomological outcomes, the overall cost effectiveness of the technology is not well studied in a resource rich setting nor under the suppression approach that aims to suppress the wild-type mosquito population through the release of Wolbachia-infected males. We used economical and epidemiological data from 2010 to 2020 to first ascertain the economic and health costs of dengue in Singapore, a high income nation where dengue is hyper-endemic. The hypothetical cost effectiveness of a national Wolbachia suppression program was then evaluated historically from 2010 to 2020. We estimated that the average economic impact of dengue in Singapore from 2010 to 2020 in constant 2010US$ ranged from $1.014 to $2.265 Billion. Using empirically derived disability weights, we estimated a disease burden of 7,645-21,262 DALYs from 2010-2020. Under an assumed steady-state running cost of a national Wolbachia suppression program in Singapore, we conservatively estimate that Wolbachia would cost an estimated $50,453-$100,907 per DALYs averted and would lead to an estimated $329.40 Million saved in economic costs over 2010 to 2020 under 40% intervention efficacy. Wolbachia releases in Singapore are expected to be highly cost-effective and its rollout must be prioritised to reduce the onward spread of dengue.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.