Evidence map›Paper›PMID 36961922›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2023

Neurexin-2 restricts synapse numbers and restrains the presynaptic release probability by an alternative splicing-dependent mechanism.

Pei-Yi Lin, Lulu Y Chen, Peng Zhou, Sung-Jin Lee, Justin H Trotter, Thomas C Südhof

RetractedOpen access · hybridAbstract readRetracted Publication
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.2field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Pei-Yi LinDepartment of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305.
Lulu Y ChenDepartment of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305.
Peng ZhouDepartment of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305.
Sung-Jin LeeDepartment of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305.
Justin H TrotterDepartment of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305.
Thomas C SüdhofDepartment of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305.
Stanford University · US

Funding

FUNCTION OF NEUREXINSR37MH052804 · NIMH · UT SOUTHWESTERN MEDICAL CENTER · PI SUDHOF, THOMAS C. · 2000 to 2019
$9.3M
Function of NeurexinsR01MH052804 · NIMH · UNIVERSITY OF TEXAS SW MED CTR/DALLAS · PI SUDHOF, THOMAS C. · 1994 to 2024
$3.7M
EPILEPSY TRAINING PROGRAMT32NS007280 · NINDS · STANFORD UNIVERSITY · PI HUGUENARD, JOHN R · 1985 to 2020
$3.6M
Role of Neurexin in Synapse Formation and MaintenanceF32MH100745 · NIMH · STANFORD UNIVERSITY · PI CHEN, LULU YIJU · 2013 to 2015
$171k
Regulation of Synapse Formation and Function by Neurexin-1 ProteolysisF32MH105040 · NIMH · STANFORD UNIVERSITY · PI TROTTER, JUSTIN HOWARD · 2014 to 2016
$158k
NIMH NIH HHS F32 MH100745NIMH NIH HHS F32 MH105040NIMH NIH HHS R01 MH052804NIMH NIH HHS R37 MH052804NINDS NIH HHS T32 NS007280
6 · The paper itself

Abstract

α- and β-neurexins are extensively alternatively spliced, presynaptic cell-adhesion molecules that are thought to organize synapse assembly. However, recent data revealed that, in the hippocampus in vivo, the deletion of one neurexin isoform,

Indexed as

Alternative SplicingSynapsesCell Adhesion MoleculesHippocampusNeural Cell Adhesion MoleculesNeuronsProtein IsoformsCell Adhesion MoleculesNeural Cell Adhesion MoleculesProtein Isoformsalternative splicingneurexinneurotransmitter releasesynapse formationsynaptic transmisssion

Identifiers

PMID36961922
PMCPMC10068831
OpenAlexW4360828038

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.