Evidence map›Paper›PMID 36961894›Full record

ArticleScience advances2023

Label-free structural and functional volumetric imaging by dual-modality optical-Raman projection tomography.

Nan Wang, Xinyu Wang, Tianyu Yan, Hui Xie, Lin Wang, Feng Ren, Dan Chen, Dongjie Zhang, Qi Zeng, Shouping Zhu and 1 more

Open access · goldAbstract read
In one paragraph

Article in Science advances, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
3.6field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Nan WangBiomedical Photonics and Molecular Imaging Laboratory, School of Life Science and Technology, Xidian University, and Xi'an Key Laboratory of Intelligent Sensing and Regulation of Trans-Scale Life Information, Xi'an, Shaanxi 710126, China.ORCID 0000-0002-6780-3401
Xinyu WangBiomedical Photonics and Molecular Imaging Laboratory, School of Life Science and Technology, Xidian University, and Xi'an Key Laboratory of Intelligent Sensing and Regulation of Trans-Scale Life Information, Xi'an, Shaanxi 710126, China.
Tianyu YanBiomedical Photonics and Molecular Imaging Laboratory, School of Life Science and Technology, Xidian University, and Xi'an Key Laboratory of Intelligent Sensing and Regulation of Trans-Scale Life Information, Xi'an, Shaanxi 710126, China.ORCID 0000-0002-2245-1537
Hui XieBiomedical Photonics and Molecular Imaging Laboratory, School of Life Science and Technology, Xidian University, and Xi'an Key Laboratory of Intelligent Sensing and Regulation of Trans-Scale Life Information, Xi'an, Shaanxi 710126, China.ORCID 0000-0002-3224-243X
Lin WangSchool of Computer Science and Engineering, Xi'an University of Technology, Xi'an, Shaanxi 710048, China.ORCID 0000-0002-5220-2929
Feng RenBiomedical Photonics and Molecular Imaging Laboratory, School of Life Science and Technology, Xidian University, and Xi'an Key Laboratory of Intelligent Sensing and Regulation of Trans-Scale Life Information, Xi'an, Shaanxi 710126, China.
Dan ChenEngineering Research Center of Molecular and Neuro Imaging, Ministry of Education, Xi'an, Shaanxi 710126, China.ORCID 0000-0002-2295-3246
Dongjie ZhangBiomedical Photonics and Molecular Imaging Laboratory, School of Life Science and Technology, Xidian University, and Xi'an Key Laboratory of Intelligent Sensing and Regulation of Trans-Scale Life Information, Xi'an, Shaanxi 710126, China.ORCID 0000-0002-1855-172X
Qi ZengBiomedical Photonics and Molecular Imaging Laboratory, School of Life Science and Technology, Xidian University, and Xi'an Key Laboratory of Intelligent Sensing and Regulation of Trans-Scale Life Information, Xi'an, Shaanxi 710126, China.ORCID 0000-0002-3563-0569
Shouping ZhuEngineering Research Center of Molecular and Neuro Imaging, Ministry of Education, Xi'an, Shaanxi 710126, China.ORCID 0000-0002-1598-6947
Xueli ChenBiomedical Photonics and Molecular Imaging Laboratory, School of Life Science and Technology, Xidian University, and Xi'an Key Laboratory of Intelligent Sensing and Regulation of Trans-Scale Life Information, Xi'an, Shaanxi 710126, China.ORCID 0000-0002-3898-9892
Ministry of Education of the People's Republic of China · CNXidian University · CNXi'an University of Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mesoscale volumetric imaging is of great importance for the study of bio-organisms. Among others, optical projection tomography provides unprecedented structural details of specimens, but it requires fluorescence label for chemical targeting. Raman spectroscopic imaging is able to identify chemical components in a label-free manner but lacks microstructure. Here, we present a dual-modality optical-Raman projection tomography (ORPT) technology, which enables label-free three-dimensional imaging of microstructures and components of millimeter-sized samples with a micron-level spatial resolution on the same device. We validate the feasibility of our ORPT system using images of polystyrene beads in a volume, followed by detecting biomolecules of zebrafish and

Indexed as

Drosophila melanogasterTomography, OpticalAnimalsImaging, Three-DimensionalSpectrum Analysis, RamanZebrafish

Identifiers

PMID36961894
PMCPMC10038343
OpenAlexW4360828769

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.