Evidence map›Paper›PMID 36961505›Full record

ArticleMicrobial genomics2023

Global scenario of the RmtE pan-aminoglycoside-resistance mechanism: emergence of the

Jose F Delgado-Blas, Cristina M Ovejero, Sophia David, Carlos Serna, Mario Pulido-Vadillo, Natalia Montero, David M Aanensen, Lorena Abadia-Patiño, Bruno Gonzalez-Zorn

Open access · goldAbstract read
In one paragraph

Article in Microbial genomics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Persistent multispecies dissemination ofJournal of clinical microbiology · 2025
    Article
  3. First Detection of High-Level Aminoglycoside-ResistantAntibiotics (Basel, Switzerland) · 2024
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Jose F Delgado-BlasAntimicrobial Resistance Unit (ARU), Animal Health Department, Faculty of Veterinary Medicine and VISAVET Health Surveillance Centre, Complutense University of Madrid (UCM), Madrid, Spain.
Cristina M OvejeroAntimicrobial Resistance Unit (ARU), Animal Health Department, Faculty of Veterinary Medicine and VISAVET Health Surveillance Centre, Complutense University of Madrid (UCM), Madrid, Spain.
Sophia DavidCentre for Genomic Pathogen Surveillance (CGPS), Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, UK.
Carlos SernaAntimicrobial Resistance Unit (ARU), Animal Health Department, Faculty of Veterinary Medicine and VISAVET Health Surveillance Centre, Complutense University of Madrid (UCM), Madrid, Spain.
Mario Pulido-VadilloAntimicrobial Resistance Unit (ARU), Animal Health Department, Faculty of Veterinary Medicine and VISAVET Health Surveillance Centre, Complutense University of Madrid (UCM), Madrid, Spain.
Natalia MonteroAntimicrobial Resistance Unit (ARU), Animal Health Department, Faculty of Veterinary Medicine and VISAVET Health Surveillance Centre, Complutense University of Madrid (UCM), Madrid, Spain.
David M AanensenCentre for Genomic Pathogen Surveillance (CGPS), Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, UK.
Lorena Abadia-PatiñoBacterial Resistance Laboratory, Department of Biomedicine, Institute for Research in Biomedicine and Applied Sciences, University of Oriente (IIBCAUDO), Cumaná, Venezuela.
Bruno Gonzalez-ZornAntimicrobial Resistance Unit (ARU), Animal Health Department, Faculty of Veterinary Medicine and VISAVET Health Surveillance Centre, Complutense University of Madrid (UCM), Madrid, Spain.
Universidad Complutense de Madrid · ESUniversidad de Oriente · VE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Antimicrobial resistance (AMR) mechanisms, especially those conferring resistance to critically important antibiotics, are a great concern for public health. 16S rRNA methyltransferases (16S-RMTases) abolish the effectiveness of most clinically used aminoglycosides, but some of them are considered sporadic, such as RmtE. The main goals of this work were the genomic analysis of bacteria producing 16S-RMTases from a 'One Health' perspective in Venezuela, and the study of the epidemiological and evolutionary scenario of RmtE variants and their related mobile genetic elements (MGEs) worldwide. A total of 21 samples were collected in 2014 from different animal and environmental sources in the Cumaná region (Venezuela). Highly aminoglycoside-resistant

Indexed as

KlebsiellaAminoglycosidesAnimalsAnti-Bacterial AgentsBacterial ProteinsHospitalsPhylogenyPlasmidsVenezuelaAminoglycosidesAnti-Bacterial AgentsBacterial Proteinsbacterial genomicsgene evolutionpan-aminoglycoside resistanceplasmid epidemiologyRmtE 16S rRNA methyltransferase

Identifiers

PMID36961505
PMCPMC10132066
OpenAlexW4360816986

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.