ArticleeLife2023
Evidence for virus-mediated oncogenesis in bladder cancers arising in solid organ transplant recipients.
Article in eLife, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 31 citations in OpenAlex.
- Virus-induced APOBEC3 transmutagenesis in bladder cancer initiation.Science advances · 2025Article
- Broadly neutralizing human monoclonal antibodies against BK polyomavirus genotypes.The Journal of general virology · 2025Article
- ISG20 RestrictsMicroorganisms · 2025Article
- Long-Term Outcomes of BK Viremia in Kidney Transplant Recipients.Clinical transplantation · 2025Article
- Oncogenic Viruses in Organ Transplantation: Implications of Virus-Host Interactions for Cancer Development.Viruses · 2025Review
- Increased cancer risk in kidney transplant patients in Scotland: a national registry linkage study.British journal of cancer · 2025Article
- Review
- Viral infections and immune modulation in bladder cancer: implications for immunotherapy.Exploration of targeted anti-tumor therapy · 2025Review
- BK Virus: Beyond Nephropathy Metastatic BK Virus-Induced, Donor-Derived Bellini's Carcinoma in a Kidney Allograft Recipient: Boosting Rejection to Treat the Cancer.Transplant international : official journal of the European Society for Organ Transplantation · 2025Article
- Multiomics Profiling Distinguishes Sebaceous Carcinoma from Benign Sebaceous Neoplasms and Provides Insight into the Genetic Evolution of Sebaceous Carcinogenesis.Clinical cancer research : an official journal of the American Association for Cancer Research · 2024Article
- Massive entry of BK Polyomavirus induces transient cytoplasmic vacuolization of human renal proximal tubule epithelial cells.PLoS pathogens · 2024Article
- Microhomology-mediated repair machinery and its relationship with HPV-mediated oncogenesis.Journal of medical virology · 2024Review
- Widespread Horizontal Gene Transfer Among Animal Viruses.bioRxiv : the preprint server for biology · 2024Article
- Torque Teno Virus (TTV)-A Potential Marker of Immunocompetence in Solid Organ Recipients.Viruses · 2023Review
- Brief Report: The Virome of Bladder Tumors Arising in People Living With HIV.Journal of acquired immune deficiency syndromes (1999) · 2023Article
- Mutational impact of APOBEC3A and APOBEC3B in a human cell line and comparisons to breast cancer.PLoS genetics · 2023Article
- Analysis of Several Common APOBEC-type Mutations in Bladder Tumors Suggests Links to Viral Infection.Cancer prevention research (Philadelphia, Pa.) · 2023Article
- Modelling BK Polyomavirus dissemination and cytopathology using polarized human renal tubule epithelial cells.PLoS pathogens · 2023Article
- A multivalent polyomavirus vaccine elicits durable neutralizing antibody responses in macaques.Vaccine · 2023Article
- Long-read sequencing reveals complex patterns of wraparound transcription in polyomaviruses.PLoS pathogens · 2022Article
Corrections and comments
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Authors and funding
20 authors at 10 institutions in 1 country.
Funding
Abstract
A small percentage of bladder cancers in the general population have been found to harbor DNA viruses. In contrast, up to 25% of tumors of solid organ transplant recipients, who are at an increased risk of developing bladder cancer and have an overall poorer outcomes, harbor BK polyomavirus (BKPyV). To better understand the biology of the tumors and the mechanisms of carcinogenesis from potential oncoviruses, we performed whole genome and transcriptome sequencing on bladder cancer specimens from 43 transplant patients. Nearly half of the tumors from this patient population contained viral sequences. The most common were from BKPyV (N=9, 21%), JC polyomavirus (N=7, 16%), carcinogenic human papillomaviruses (N=3, 7%), and torque teno viruses (N=5, 12%). Immunohistochemistry revealed variable Large T antigen expression in BKPyV-positive tumors ranging from 100% positive staining of tumor tissue to less than 1%. In most cases of BKPyV-positive tumors, the viral genome appeared to be clonally integrated into the host chromosome consistent with microhomology-mediated end joining and coincided with focal amplifications of the tumor genome similar to other virus-mediated cancers. Significant changes in host gene expression consistent with the functions of BKPyV Large T antigen were also observed in these tumors. Lastly, we identified four mutation signatures in our cases, with those attributable to APOBEC3 and SBS5 being the most abundant. Mutation signatures associated with an antiviral drug, ganciclovir, and aristolochic acid, a nephrotoxic compound found in some herbal medicines, were also observed. The results suggest multiple pathways to carcinogenesis in solid organ transplant recipients with a large fraction being virus-associated.
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