Evidence map›Paper›PMID 36961472›Full record

ArticleAnnals of the New York Academy of Sciences2023

Exosomes, microvesicles, and other extracellular vesicles-a Keystone Symposia report.

Jennifer Cable, Kenneth W Witwer, Robert J Coffey, Aleksandar Milosavljevic, Ariana K von Lersner, Lizandra Jimenez, Ferdinando Pucci, Maureen M Barr, Niek Dekker, Bahnisikha Barman and 22 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of the New York Academy of Sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Glucosylceramides trigger the shedding of alpha-synuclein laden ectosomes.Extracellular vesicles and circulating nucleic acids · 2026
    Article
  5. Review
  6. Review
  7. Review
  8. Review
  9. Article
  10. Extracellular vesicles: innovative cell-free solutions for wound repair.Frontiers in bioengineering and biotechnology · 2025
    Review
  11. Review
  12. Review
  13. Review
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

32 authors.

Jennifer CablePhD Science Writer, New York, New York, USA.
Kenneth W WitwerDepartment of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Robert J CoffeyDepartment of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Aleksandar MilosavljevicDepartment of Molecular and Human Genetics; Dan L Duncan Comprehensive Cancer Center; and Program in Quantitative and Computational Biosciences, Baylor College of Medicine, Houston, Texas, USA.
Ariana K von LersnerProgram in Cancer Biology, Vanderbilt University, Nashville, Tennessee, USA.
Lizandra JimenezDepartment of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Ferdinando PucciDepartment of Otolaryngology-Head and Neck Surgery; Department of Cell, Developmental & Cancer Biology; Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon, USA.
Maureen M BarrDepartment of Genetics and Human Genetics Institute of New Jersey, Rutgers, The State University of New Jersey, Piscataway, New Jersey, USA.
Niek DekkerProtein Sciences, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.
Bahnisikha BarmanDepartment of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Daniel HumphrysUniversity of Washington, Seattle, Washington, USA.
Justin WilliamsUniversity of California, Berkeley, Berkeley, California, USA.
Michele de PalmaSwiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, Swiss Federal Institute of Technology in Lausanne (EPFL); Agora Cancer Research Center; and Swiss Cancer Center Léman (SCCL), Lausanne, Switzerland.
Wei GuoDepartment of Biology, School of Arts & Sciences, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Nuno Bastosi3S Instituto de Investigação e Inovação em Saúde; IPATIMUP Institute of Molecular Pathology and Immunology; and ICBAS Instituto de Ciencias Biomédicas Abel Salazar, University of Porto, Porto, Portugal.
Andrew F HillResearch Centre for Extracellular Vesicles; Department of Biochemistry and Chemistry, School of Agriculture, Biomedicine and Environment, La Trobe University and Institute for Health and Sport, Victoria University, Melbourne, Victoria, Australia.
Efrat LevyCenter for Dementia Research, Nathan S. Kline Institute for Psychiatric Research, Orangeburg, New York, USA.
Michael P HantakDepartment of Neurobiology and Anatomy, University of Utah, Salt Lake City, Utah, USA.
Clair CreweTouchstone Diabetes Center, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Elena AikawaCenter for Interdisciplinary Cardiovascular Sciences, Division of Cardiovascular Medicine and Center for Excellence in Vascular Biology, Department of Medicine; Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Alan M AdamczykUniversity of Buenos Aires, Buenos Aires, Argentina.
Tamires M ZanottoSection of Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts, USA.
Matias OstrowskiFacultad de Medicina, Instituto de Investigaciones Biomédicas en Retrovirus y Sida (INBIRS), Universidad de Buenos Aires (UBA) and Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina.
Tanina ArabDepartment of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Daniel C RabeMass General Cancer Center, Harvard Medical School, Charlestown, Massachusetts, USA.
Aadil SheikhDepartment of Biology, College of Arts and Sciences, Baylor University, Waco, Texas, USA.
Danilo Rodrigues da SilvaUniversity of Florida, Gainesville, Florida, USA.
Jennifer C JonesTranslational Nanobiology Section, Laboratory of Pathology and Vaccine Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
Chioma OkeomaDepartment of Pharmacology, Stony Brook University Renaissance School of Medicine, Stony Brook, New York, USA.
Thomas GaborskiSchool of Chemistry and Materials Science, Rochester Institute of Technology, Rochester, New York, USA.
Qin ZhangDepartment of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Olesia GololobovaDepartment of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Funding

Washington University Nutrition Obesity Research CenterP30DK056341 · NIDDK · WASHINGTON UNIVERSITY · PI Brian N Finck · 1999 to 2026
$30.2M
Development and use of nanoFACS for analysis and sorting of nanoparticlesZIABC011502 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI JONES, JENNIFER · 2013 to 2025
$8.6M
Novel Combinations of Radiation and ImmunotherapyZIABC011503 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI JONES, JENNIFER · 2013 to 2025
$5.3M
Next-generation extracellular vesicle biologics to target central nervous system and peripheral reservoirs of HIVR01AI144997 · NIAID · JOHNS HOPKINS UNIVERSITY · PI RAMRATNAM, BHARAT, WITWER, KENNETH W · 2019 to 2023
$4.0M
Extracellular Vesicle and Extracellular RNA Biomarkers of HIV-1 Central Nervous System Pathogenesis and Cigarette UseR01DA047807 · NIDA · JOHNS HOPKINS UNIVERSITY · PI WITWER, KENNETH W · 2018 to 2022
$3.7M
Novel Approaches to Capture, Sorting, and Characterization of CNS-Origin Extracellular VesiclesR33MH118164 · NIMH · JOHNS HOPKINS UNIVERSITY · PI MACHAIRAKI, VASILIKI, WITWER, KENNETH W · 2020 to 2022
$2.2M
Novel Separation Methods for exRNA Carriers: Extracellular Vesicles, Lipoprotein Particles, and Protein AggregatesUH3CA241694 · NCI · JOHNS HOPKINS UNIVERSITY · PI WITWER, KENNETH W · 2021 to 2022
$1.1M
Intramural NIH HHS ZIA BC011502NCI NIH HHS UH3 CA241694NIAID NIH HHS R01 AI144997NIDA NIH HHS R01 DA047807NIDDK NIH HHS P30 DK056341NIMH NIH HHS R33 MH118164
6 · The paper itself

Abstract

Extracellular vesicles (EVs) are small, lipid-bilayer-bound particles released by cells that can contain important bioactive molecules, including lipids, RNAs, and proteins. Once released in the extracellular environment, EVs can act as messengers locally as well as to distant tissues to coordinate tissue homeostasis and systemic responses. There is a growing interest in not only understanding the physiology of EVs as signaling particles but also leveraging them as minimally invasive diagnostic and prognostic biomarkers (e.g., they can be found in biofluids) and drug-delivery vehicles. On October 30-November 2, 2022, researchers in the EV field convened for the Keystone symposium "Exosomes, Microvesicles, and Other Extracellular Vesicles" to discuss developing standardized language and methodology, new data on the basic biology of EVs and potential clinical utility, as well as novel technologies to isolate and characterize EVs.

Indexed as

Cell-Derived MicroparticlesExosomesExtracellular VesiclesHumansRNARNAexomereexosomeextracellular RNAextracellular vesiclemitovesiclesupermere

Identifiers

PMID36961472
PMCPMC10715677

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.