Evidence map›Paper›PMID 36961351›Full record

ArticleJournal of orthopaedic research : official publication of the Orthopaedic Research Society2023

iPSC-derived tenocytes seeded on microgrooved 3D printed scaffolds for Achilles tendon regeneration.

Giselle Kaneda, Julie L Chan, Chloe M Castaneda, Angela Papalamprou, Julia Sheyn, Oksana Shelest, Dave Huang, Nadine Kluser, Victoria Yu, Gian C Ignacio and 6 more

Open access · greenAbstract read
In one paragraph

Article in Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Review
  8. Tendon mechanobiology in the context of tendon biofabrication.Frontiers in bioengineering and biotechnology · 2025
    Review
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 2 institutions in 2 countries.

Giselle KanedaOrthopaedic Stem Cell Research Laboratory, Cedars-Sinai Medical Center, Los Angeles, California, USA.ORCID 0000-0002-0547-9060
Julie L ChanOrthopaedic Stem Cell Research Laboratory, Cedars-Sinai Medical Center, Los Angeles, California, USA.ORCID 0000-0002-0782-6548
Chloe M CastanedaOrthopaedic Stem Cell Research Laboratory, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Angela PapalamprouOrthopaedic Stem Cell Research Laboratory, Cedars-Sinai Medical Center, Los Angeles, California, USA.ORCID 0000-0002-0496-2501
Julia SheynOrthopaedic Stem Cell Research Laboratory, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Oksana ShelestBoard of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Dave HuangOrthopedics Biomechanics Laboratory, Cedars-Sinai Medical Center, Los Angeles, California, USA.ORCID 0000-0003-0332-5823
Nadine KluserAO Research Institute Davos, Davos, Switzerland.
Victoria YuOrthopaedic Stem Cell Research Laboratory, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Gian C IgnacioOrthopedics Biomechanics Laboratory, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Arkadiusz GertychDepartment of Surgery, Cedars-Sinai Medical Center, Los Angeles, California, USA.ORCID 0000-0002-3107-602X
Ryu YoshidaDepartment of Orthopedics, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Melodie F MetzgerOrthopedics Biomechanics Laboratory, Cedars-Sinai Medical Center, Los Angeles, California, USA.ORCID 0000-0001-8892-7035
Wafa TawackoliOrthopaedic Stem Cell Research Laboratory, Cedars-Sinai Medical Center, Los Angeles, California, USA.ORCID 0000-0003-3742-8644
Andrea VernengoAO Research Institute Davos, Davos, Switzerland.ORCID 0000-0002-5143-7435
Dmitriy SheynOrthopaedic Stem Cell Research Laboratory, Cedars-Sinai Medical Center, Los Angeles, California, USA.ORCID 0000-0002-3333-1485
Cedars-Sinai Medical Center · USAO Foundation · CH

Funding

Induced pluripotent stem cell therapy for degenerated IVDK01AR071512 · NIAMS · CEDARS-SINAI MEDICAL CENTER · PI SHEYN, DMITRIY · 2018 to 2022
$595k
NIAMS NIH HHS K01 AR071512
6 · The paper itself

Abstract

Tendons and ligaments have a poor innate healing capacity, yet account for 50% of musculoskeletal injuries in the United States. Full structure and function restoration postinjury remains an unmet clinical need. This study aimed to assess the application of novel three dimensional (3D) printed scaffolds and induced pluripotent stem cell-derived mesenchymal stem cells (iMSCs) overexpressing the transcription factor Scleraxis (SCX, iMSC

Indexed as

Achilles TendonInduced Pluripotent Stem CellsAnimalsPrinting, Three-DimensionalRatsRegenerationTenocytesTissue EngineeringTissue ScaffoldsWound HealingAchilles tendoniPSCmicrogroovesscaffoldscleraxis

Identifiers

PMID36961351
PMCPMC10518032
OpenAlexW4360817428

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.