Evidence map›Paper›PMID 36961222›Full record

ArticleACS infectious diseases2023

Optimization of Host Cell-Compatible, Antimicrobial Peptides Effective against Biofilms and Clinical Isolates of Drug-Resistant Bacteria.

Jenisha Ghimire, Robert J Hart, Anabel Soldano, Charles H Chen, Shantanu Guha, Joseph P Hoffmann, Kalen M Hall, Leisheng Sun, Benjamin J Nelson, Timothy K Lu and 4 more

Open access · hybridAbstract read
In one paragraph

Article in ACS infectious diseases, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Review
  3. Killing of colistin-resistantMicrobiology spectrum · 2025
    Article
  4. Article
  5. Review
  6. Article
  7. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Jenisha GhimireDepartment of Biochemistry and Molecular Biology, Tulane University School of Medicine, New Orleans, Louisiana 70112, United States.
Robert J HartDepartment of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, Louisiana 70112, United States.
Anabel SoldanoDepartment of Chemistry, Louisiana State University, Baton Rouge, Louisiana 70803, United States.
Charles H ChenSynthetic Biology Group, Research Laboratory of Electronics, Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts 02139, United States.ORCID 0000-0001-7695-5215
Shantanu GuhaDepartment of Biochemistry and Molecular Biology, Tulane University School of Medicine, New Orleans, Louisiana 70112, United States.ORCID 0000-0002-7027-0183
Joseph P HoffmannDepartment of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, Louisiana 70112, United States.
Kalen M HallDepartment of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, Louisiana 70112, United States.
Leisheng SunDepartment of Biochemistry and Molecular Biology, Tulane University School of Medicine, New Orleans, Louisiana 70112, United States.ORCID 0000-0003-0358-1421
Benjamin J NelsonDepartment of Biochemistry and Molecular Biology, Tulane University School of Medicine, New Orleans, Louisiana 70112, United States.ORCID 0000-0001-8529-4850
Timothy K LuSynthetic Biology Group, Research Laboratory of Electronics, Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts 02139, United States.ORCID 0000-0002-3918-8923
Jay K KollsDepartment of Medicine, Tulane University School of Medicine, New Orleans, Louisiana 70112, United States.
Mario RiveraDepartment of Chemistry, Louisiana State University, Baton Rouge, Louisiana 70803, United States.ORCID 0000-0002-5692-5497
Lisa A MoriciDepartment of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, Louisiana 70112, United States.
William C WimleyDepartment of Biochemistry and Molecular Biology, Tulane University School of Medicine, New Orleans, Louisiana 70112, United States.ORCID 0000-0003-2967-5186
Tulane University · USLouisiana State University · USMassachusetts Institute of Technology · US

Funding

Training in CD4 T-cell Lung ImmunityR35HL139930 · NHLBI · TULANE UNIVERSITY OF LOUISIANA · PI KOLLS, JAY K · 2018 to 2024
$6.3M
Small molecules for perturbing iron homeostasis in bacterial biofilmsR01AI169344 · NIAID · LOUISIANA STATE UNIV A&M COL BATON ROUGE · PI Mario Rivera · 2022 to 2026
$3.7M
Development of Novel Adjuvants LTA and LTA1R01AI114697 · NIAID · TULANE UNIVERSITY OF LOUISIANA · PI NORTON, ELIZABETH B · 2015 to 2019
$2.1M
Molecular evolution of Peptide antibiotics for drug-resistant Gram negative bacteriaR21AI119104 · NIAID · TULANE UNIVERSITY OF LOUISIANA · PI WIMLEY, WILLIAM C · 2015 to 2016
$405k
NHLBI NIH HHS R35 HL139930NIAID NIH HHS R01 AI114697NIAID NIH HHS R01 AI169344NIAID NIH HHS R21 AI119104
6 · The paper itself

Abstract

Here, we describe the continued synthetic molecular evolution of a lineage of host-compatible antimicrobial peptides (AMP) intended for the treatment of wounds infected with drug-resistant, biofilm-forming bacteria. The peptides tested are variants of an evolved AMP called d-amino acid CONsensus with Glycine Absent (d-CONGA), which has excellent antimicrobial activities

Indexed as

Anti-Infective AgentsAntimicrobial Cationic PeptidesBacteriaBiofilmsHumansMicrobial Sensitivity TestsAnti-Infective AgentsAntimicrobial Cationic Peptidesantibioticantimicrobial peptidedrug resistancemolecular evolution

Identifiers

PMID36961222
PMCPMC10111420
OpenAlexW4360808620

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.