Evidence map›Paper›PMID 36961104›Full record

ReviewAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2023

Ultrasound Neuromodulation as a New Brain Therapy.

Roland Beisteiner, Mark Hallett, Andres M Lozano

Registry-linked trialOpen access · goldAbstract readReview
In one paragraph

Review in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06178952 (Transcranial Pulse Stimulation), which is not on this map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
8.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06178952 narecruitingnot on this mapstarted 2024, after this paper: background citation

Transcranial Pulse Stimulation (TPS) in Post-COVID-19

TypeinterventionalSponsorMedical University of ViennaRan2024 to 2027Enrolled102ConditionsPost-COVID-19 Syndrome, FatigueArmsTranscranial pulse stimulation Verum, Transcranial pulse stimulation Sham
3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 76 citations in OpenAlex.

  1. Transcranial Pulse Stimulation Enhances Dexterity in Parkinson's Disease: A Randomized Sham-Controlled Trial.Movement disorders : official journal of the Movement Disorder Society · 2026
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  6. Ultrasound Modulation of Visual Circuits in Mice Independent of Auditory Confound.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
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  8. Article
  9. Review
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  13. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 3 countries.

Roland BeisteinerDepartment of Neurology, Functional Brain Diagnostics and Therapy, High Field MR Center, Medical University of Vienna, Spitalgasse 23, Vienna, 1090, Austria.ORCID 0000-0002-6410-5990
Mark HallettHuman Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 10 Center Drive, Bethesda, MD, 20892-1428, USA.
Andres M LozanoDivision of Neurosurgery, Department of Surgery, University of Toronto, Toronto, ON, M5T 2S8, Canada.
Medical University of Vienna · ATNational Institutes of Health · USUniversity of Toronto · CA

Funding

Herzfelder Stiftung, Austria
6 · The paper itself

Abstract

Within the last decade, ultrasound has been "rediscovered" as a technique for brain therapies. Modern technologies allow focusing ultrasound through the human skull for highly focal tissue ablation, clinical neuromodulatory brain stimulation, and targeted focal blood-brain-barrier opening. This article gives an overview on the state-of-the-art of the most recent application: ultrasound neuromodulation as a new brain therapy. Although research centers have existed for decades, the first treatment centers were not established until 2020, and clinical applications are spreading rapidly.

Indexed as

Blood-Brain BarrierBrainHumansUltrasonographybrain stimulationbrain therapyfocused ultrasoundtranscranial pulse stimulation

Identifiers

PMID36961104
PMCPMC10190662
OpenAlexW4360815437

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.