Evidence map›Paper›PMID 36961005›Full record

ArticleTomography (Ann Arbor, Mich.)2023

Integrated Small Animal PET/CT/RT with Onboard PET/CT Image Guidance for Preclinical Radiation Oncology Research.

Xinyi Cheng, Dongxu Yang, Debabrata Saha, Xiankai Sun, Yiping Shao

Open access · goldFull text read
In one paragraph

Article in Tomography (Ann Arbor, Mich.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. [Advances in multimodal biomedical imaging of small animals].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Xinyi ChengDepartment of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Dongxu YangDepartment of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0002-3729-9216
Debabrata SahaDepartment of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Xiankai SunSimmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0002-5140-6110
Yiping ShaoDepartment of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
The University of Texas Southwestern Medical Center · USSouthwestern Medical Center · US

Funding

University of Texas Southwestern Medical Center SPORE in Kidney CancerP50CA196516 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI James Brugarolas · 2016 to 2026
$24.7M
Novel On-line PET Based Intra-Beam Range Verification and Delivery Optimization for Improved Particle Radiation TherapyR01CA218402 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI LU, WEIGUO, SHAO, YIPING · 2018 to 2022
$2.2M
Advanced micro-PET/CT/RT System for Translational Radiation Oncology ApplicationsR01EB019438 · NIBIB · UT SOUTHWESTERN MEDICAL CENTER · PI SHAO, YIPING · 2015 to 2020
$1.5M
Flexible, ultrahigh-throughput and easy-implementing distributed coincidence processor for improving PET imaging performanceR03EB032476 · NIBIB · UT SOUTHWESTERN MEDICAL CENTER · PI SHAO, YIPING · 2022 to 2023
$164k
NCI NIH HHS P50 CA196516NCI NIH HHS R01 CA218402NIBIB NIH HHS R01 EB019438NIBIB NIH HHS R03 EB032476
6 · The paper itself

Abstract

We have integrated a compact and lightweight PET with an existing CT image-guided small animal irradiator to enable practical onboard PET/CT image-guided preclinical radiation therapy (RT) research. The PET with a stationary and full-ring detectors has ~1.1 mm uniform spatial resolution over its imaging field-of-view of 8.0 cm diameter and 3.5 cm axial length and was mechanically installed inside the irradiator in a tandem configuration with CT and radiation unit. A common animal bed was used for acquiring sequential dual functional and anatomical images with independent PET and CT control and acquisition systems. The reconstructed dual images were co-registered based on standard multi-modality image calibration and registration processes. Phantom studies were conducted to evaluate the integrated system and dual imaging performance. The measured mean PET/CT image registration error was ~0.3 mm. With one-bed and three-bed acquisitions, initial tumor focused and whole-body [

Indexed as

Positron Emission Tomography Computed TomographyRadiation OncologyAnimalsFluorodeoxyglucose F18Phantoms, ImagingFluorodeoxyglucose F18onboard PET/CT imagePET/CT/RTpreclinical radiotherapy researchsmall animal PET

Identifiers

PMID36961005
PMCPMC10037572
OpenAlexW4323312540

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read10
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.