Evidence map›Paper›PMID 36960443›Full record

ArticlePatterns (New York, N.Y.)2023

Leveraging quantum computing for dynamic analyses of logical networks in systems biology.

Felix M Weidner, Julian D Schwab, Sabine Wölk, Felix Rupprecht, Nensi Ikonomi, Silke D Werle, Steve Hoffmann, Michael Kühl, Hans A Kestler

Open access · goldFull text read
In one paragraph

Article in Patterns (New York, N.Y.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
2.6field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. A primer for quantum computing and its applications to healthcare and biomedical research.Journal of the American Medical Informatics Association : JAMIA · 2024
    Article
  6. Review
  7. The Future of Drug Development with Quantum Computing.Methods in molecular biology (Clifton, N.J.) · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Felix M WeidnerInstitute of Medical Systems Biology, Ulm University, 89081 Ulm, Germany.
Julian D SchwabInstitute of Medical Systems Biology, Ulm University, 89081 Ulm, Germany.
Sabine WölkInstitute of Quantum Technologies, DLR Ulm, 89081 Ulm, Germany.
Felix RupprechtInstitute of Quantum Technologies, DLR Ulm, 89081 Ulm, Germany.
Nensi IkonomiInstitute of Medical Systems Biology, Ulm University, 89081 Ulm, Germany.
Silke D WerleInstitute of Medical Systems Biology, Ulm University, 89081 Ulm, Germany.
Steve HoffmannLeibniz Institute on Aging, Fritz Lipmann Institute, 07745 Jena, Germany.
Michael KühlInstitute of Biochemistry and Molecular Biology, Ulm University, 89081 Ulm, Germany.
Hans A KestlerInstitute of Medical Systems Biology, Ulm University, 89081 Ulm, Germany.
Universität Ulm · DECenter for Integrated Quantum Science and Technology · DELeibniz Institute on Aging - Fritz Lipmann Institute (FLI) · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The dynamics of cellular mechanisms can be investigated through the analysis of networks. One of the simplest but most popular modeling strategies involves logic-based models. However, these models still face exponential growth in simulation complexity compared with a linear increase in nodes. We transfer this modeling approach to quantum computing and use the upcoming technique in the field to simulate the resulting networks. Leveraging logic modeling in quantum computing has many benefits, including complexity reduction and quantum algorithms for systems biology tasks. To showcase the applicability of our approach to systems biology tasks, we implemented a model of mammalian cortical development. Here, we applied a quantum algorithm to estimate the tendency of the model to reach particular stable conditions and further revert dynamics. Results from two actual quantum processing units and a noisy simulator are presented, and current technical challenges are discussed.

Indexed as

Boolean networkscortical area development networkgene-regulatory networksquantum algorithmsquantum computingsystems biology

Identifiers

PMID36960443
PMCPMC10028428
OpenAlexW4323835315

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read18
table measurements read16
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.