ArticleFrontiers in cell and developmental biology2023
Blimp-1/PRDM1 and Hr3/RORβ specify the blue-sensitive photoreceptor subtype in
Article in Frontiers in cell and developmental biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed, 3 citations in OpenAlex.
- miR-927 Regulates Photoreceptor Subtype Specification Through Yorkie and Sensory Opsins inCells · 2026Article
- Cis-regulatory evolution reveals sensory trade-offs as a genetic basis for temporal niche evolution in tapirs.Science advances · 2026Article
- PRDM1 promotes the stemness of gastric cancer cells by enhancing the transactivation of Myc.Translational oncology · 2025Article
- Same rule, different genes:Science advances · 2024Article
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Authors and funding
11 authors at 4 institutions in 2 countries.
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Abstract
During terminal differentiation of the mammalian retina, transcription factors control binary cell fate decisions that generate functionally distinct subtypes of photoreceptor neurons. For instance, Otx2 and RORβ activate the expression of the transcriptional repressor Blimp-1/PRDM1 that represses bipolar interneuron fate and promotes rod photoreceptor fate. Moreover, Otx2 and Crx promote expression of the nuclear receptor Nrl that promotes rod photoreceptor fate and represses cone photoreceptor fate. Mutations in these four transcription factors cause severe eye diseases such as retinitis pigmentosa. Here, we show that a post-mitotic binary fate decision in
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