Evidence map›Paper›PMID 36960404›Full record

ArticleDystonia (Lausanne, Switzerland)2022

Quantification of Behavioral Deficits in Developing Mice With Dystonic Behaviors.

Meike E Van Der Heijden, Jason S Gill, Alejandro G Rey Hipolito, Luis E Salazar Leon, Roy V Sillitoe

Open access · diamondFull text read
In one paragraph

Article in Dystonia (Lausanne, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 20 citations in OpenAlex.

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  10. Thalamic deep brain stimulation improves movement in a cerebellar model of lesion-based status dystonicus.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025
    Article
  11. Article
  12. More Than a Small Brain: The Importance of Studying Neural Function during Development.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Meike E Van Der HeijdenDepartment of Pathology & Immunology, Baylor College of Medicine, Houston, TX, United States.
Jason S GillJan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, TX, United States.
Alejandro G Rey HipolitoDepartment of Pathology & Immunology, Baylor College of Medicine, Houston, TX, United States.
Luis E Salazar LeonDepartment of Pathology & Immunology, Baylor College of Medicine, Houston, TX, United States.
Roy V SillitoeDepartment of Pathology & Immunology, Baylor College of Medicine, Houston, TX, United States.
Center for Neurosciences · USTexas Children's Hospital · USPediatrics and Genetics · US

Funding

Preclinical and Clincial OutcomesP50HD103555 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI Sandesh Chakravarthy Sreenath Nagamani, David Loren Nelson · 2020 to 2026
$9.9M
Cerebellar Deep Brain StimulationR01NS119301 · NINDS · BAYLOR COLLEGE OF MEDICINE · PI SILLITOE, ROY VINCENT · 2020 to 2024
$2.0M
Spatial and temporal pathophysiology of developmental dystoniaR01NS127435 · NINDS · BAYLOR COLLEGE OF MEDICINE · PI Roy Vincent Sillitoe · 2022 to 2026
$2.0M
CEREBELLAR FUNCTION IN TREMORR01NS100874 · NINDS · BAYLOR COLLEGE OF MEDICINE · PI SILLITOE, ROY VINCENT · 2017 to 2021
$1.9M
Unraveling the Dynamic Role of Purkinje Cell Neurotransmission in Neurodevelopment.K08NS121600 · NINDS · BAYLOR COLLEGE OF MEDICINE · PI GILL, JASON SINGH · 2021 to 2025
$956k
NICHD NIH HHS P50 HD103555NINDS NIH HHS K08 NS121600NINDS NIH HHS R01 NS100874NINDS NIH HHS R01 NS119301NINDS NIH HHS R01 NS127435
6 · The paper itself

Abstract

Converging evidence from structural imaging studies in patients, the function of dystonia-causing genes, and the comorbidity of neuronal and behavioral defects all suggest that pediatric-onset dystonia is a neurodevelopmental disorder. However, to fully appreciate the contribution of altered development to dystonia, a mechanistic understanding of how networks become dysfunctional is required for early-onset dystonia. One current hurdle is that many dystonia animal models are ideally suited for studying adult phenotypes, as the neurodevelopmental features can be subtle or are complicated by broad developmental deficits. Furthermore, most assays that are used to measure dystonia are not suited for developing postnatal mice. Here, we characterize the early-onset dystonia in

Indexed as

behaviorcerebellumdevelopmentdystonianeurodevelopmental disorders

Identifiers

PMID36960404
PMCPMC10032351
OpenAlexW4297837466

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read4
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.