Evidence map›Paper›PMID 36960209›Full record

ArticleFrontiers in nutrition2023

Anti-cancer potential of synergistic phytochemical combinations is influenced by the genetic profile of prostate cancer cell lines.

Carol A Gano, Shadma Fatima, Timothy W Failes, Gregory M Arndt, Mila Sajinovic, David Mahns, Ahmad Saedisomeolia, Jens R Coorssen, Joseph Bucci, Paul de Souza and 2 more

Open access · goldFull text read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in nutrition, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 8 institutions in 2 countries.

Carol A GanoSchool of Medicine, Western Sydney University, Campbelltown, NSW, Australia.
Shadma FatimaSchool of Medicine, Western Sydney University, Campbelltown, NSW, Australia.
Timothy W FailesACRF Drug Discovery Centre, Children's Cancer Institute, Lowy Cancer Research Centre, UNSW Sydney, Sydney, NSW, Australia.
Gregory M ArndtACRF Drug Discovery Centre, Children's Cancer Institute, Lowy Cancer Research Centre, UNSW Sydney, Sydney, NSW, Australia.
Mila SajinovicIngham Institute of Applied Medical Research, Liverpool, NSW, Australia.
David MahnsSchool of Medicine, Western Sydney University, Campbelltown, NSW, Australia.
Ahmad SaedisomeoliaSchool of Human Nutrition, McGill University, Sainte Anne-de-Bellevue, QC, Canada.
Jens R CoorssenDepartments of Health Sciences and Biological Sciences, Faculties of Applied Health Science, and Mathematics and Science, Brock University, St. Catharines, ON, Canada.
Joseph BucciSt George Hospital Clinical School, UNSW, Kogarah, NSW, Australia.
Paul de SouzaSchool of Medicine, Western Sydney University, Campbelltown, NSW, Australia.
Fatemeh VafaeeSchool of Biotechnology and Biological Sciences, UNSW Sydney, Sydney, NSW, Australia.
Kieran F ScottSchool of Medicine, Western Sydney University, Campbelltown, NSW, Australia.
UNSW Sydney · AUCamden and Campbelltown Hospitals · AUWestern Sydney University · AUBrock University · CACancer Institute of New South Wales · AUIngham Institute · AUMcGill University · CASt George Hospital · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Despite strong epidemiological evidence that dietary factors modulate cancer risk, cancer control through dietary intervention has been a largely intractable goal for over sixty years. The effect of tumour genotype on synergy is largely unexplored. Methods: The effect of seven dietary phytochemicals, quercetin (0-100 μM), curcumin (0-80 μM), genistein, indole-3-carbinol (I3C), equol, resveratrol and epigallocatechin gallate (EGCG) (each 0-200 μM), alone and in all paired combinations om cell viability of the androgen-responsive, pTEN-null (LNCaP), androgen-independent, pTEN-null (PC-3) or androgen-independent, pTEN-positive (DU145) prostate cancer (PCa) cell lines was determined using a high throughput alamarBlue Results: Synergy was observed with all combinations. In LNCaP and PC-3 cells, I3C mediated maximum synergy with five phytochemicals, while genistein was maximally synergistic with EGCG. In contrast, DU145 cells showed resveratrol-mediated maximum synergy with equol, EGCG and genistein, with I3C mediating maximum synergy with only quercetin and curcumin. Knockdown of pTEN expression in DU145 cells abrogated the synergistic effect of resveratrol without affecting the synergy profile of I3C and quercetin. Discussion: Our study identifies patterns of synergy that are dependent on tumour cell genotype and are independent of androgen signaling but are dependent on pTEN. Despite evident cell-type specificity in both maximally-synergistic combinations and the pathways that phytochemicals modulate, these combinations interact with similar prostate cancer protein targets. Here, we identify an approach that, when coupled with advanced data analysis methods, may suggest optimal dietary phytochemical combinations for individual consumption based on tumour molecular profile.Graphical abstract.

Indexed as

Blissnetwork pharmacologyphytochemicalsprostate cancerpTEN losssynergistic combinations

Identifiers

PMID36960209
PMCPMC10029761
OpenAlexW4323569529

What OpenQuestion holds

Textfull text, public
LicenceCC BY
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.