Evidence map›Paper›PMID 36960086›Full record

ArticleAntimicrobial stewardship & healthcare epidemiology : ASHE2023

Dispensing of antibiotics without prescription in the metropolitan area of Athens, Greece, in 2021-Can new legislation change old habits?

Ioannis Kopsidas, Lydia Kokkinidou, Dioni Pinelopi Petsiou, Eleni Kourkouni, Christos Triantafyllou, Grammatiki-Christina Tsopela, Theoklis Zaoutis

Open access · goldFull text read
In one paragraph

Article in Antimicrobial stewardship & healthcare epidemiology : ASHE, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Ioannis KopsidasSecond Department of Pediatrics, National and Kapodisitrian University, Athens, Greece.ORCID https://orcid.org/0000-0001-6499-4807
Lydia KokkinidouCenter for Clinical Epidemiology and Outcomes Research, Athens, Greece.ORCID https://orcid.org/0000-0001-9502-2453
Dioni Pinelopi PetsiouCenter for Clinical Epidemiology and Outcomes Research, Athens, Greece.ORCID https://orcid.org/0000-0003-1881-2982
Eleni KourkouniCenter for Clinical Epidemiology and Outcomes Research, Athens, Greece.
Christos TriantafyllouCenter for Clinical Epidemiology and Outcomes Research, Athens, Greece.ORCID https://orcid.org/0000-0002-3198-3965
Grammatiki-Christina TsopelaCenter for Clinical Epidemiology and Outcomes Research, Athens, Greece.ORCID https://orcid.org/0000-0003-3662-0140
Theoklis ZaoutisSecond Department of Pediatrics, National and Kapodisitrian University, Athens, Greece.
National and Kapodistrian University of Athens · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To assess the effect of new legislation on the dispensing of antimicrobials without prescription from pharmacies in Greece. Design: In-person survey. Setting: The study included 110 pharmacies in the greater Athens Metropolitan area. Methods: Volunteer collaborators visited 110 pharmacies in the greater Athens Metropolitan area in December 2021 and January 2022. They asked for either ciprofloxacin or amoxicillin-clavulanate acid (6:5 ratio) without providing a prescription, without simulating symptoms, and without offering justification or insisting. Fluoroquinolones have additional dispensing restrictions in Greece. Results were compared to a 2008 study. In 2020, legislation allowed the dispensing of antibiotics from pharmacies only with an electronic prescription, overriding the 1973 forbidding the dispensing of all medications without prescriptions. Results: All pharmacists refused to dispense ciprofloxacin without a prescription. Only 1 pharmacy dispensed amoxicillin-clavulanate without a prescription. Compared to the 2008 study, dispensing of amoxicillin-clavulanate without a prescription dropped from 100% in 2008 to 1% in 2021 and dispensing ciprofloxacin without a prescription dropped from 53% in 2008 to 0% in 2021. Conclusions: A new and enforced law that requires electronic prescribing led to a dramatic reduction of antibiotic dispensing without prescription compared to 12 years ago. Similar initiatives could help solve the problem of antibiotic consumption and resistance in Greece and elsewhere.

Identifiers

PMID36960086
PMCPMC10028989
OpenAlexW4323024739

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read16
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.