Evidence map›Paper›PMID 36959687›Full record

ArticleEuropean journal of immunology2023

Immunomodulation of neutrophil granulocyte functions by bacterial polyphosphates.

Viola Krenzlin, Johannes Schöche, Sarah Walachowski, Christoph Reinhardt, Markus P Radsak, Markus Bosmann

Open access · hybridAbstract read
In one paragraph

Article in European journal of immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Inorganic Polyphosphate and Human Diseases.Progress in molecular and subcellular biology · 2026
    Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Viola KrenzlinCenter for Thrombosis and Hemostasis, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany.
Johannes SchöcheCenter for Thrombosis and Hemostasis, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany.
Sarah WalachowskiPulmonary Center, Department of Medicine, Boston University School of Medicine, Boston, MA, USA.
Christoph ReinhardtCenter for Thrombosis and Hemostasis, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany.ORCID 0000-0002-0696-2636
Markus P RadsakThird Department of Medicine-Hematology and Oncology, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany.ORCID 0000-0002-3991-5721
Markus BosmannCenter for Thrombosis and Hemostasis, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany.ORCID 0000-0003-2773-1033
Johannes Gutenberg University Mainz · DEBoston University · US

Funding

Bacterial polyphosphates in sepsisR01AI153613 · NIAID · BOSTON UNIVERSITY MEDICAL CAMPUS · PI BOSMANN, MARKUS · 2021 to 2024
$2.1M
NIAID NIH HHS R01 AI153613
6 · The paper itself

Abstract

Polyphosphates are highly conserved, linear polymers of monophosphates that reside in all living cells. Bacteria produce long chains containing hundreds to thousands of phosphate units, which can interfere with host defense to infection. Here, we report that intratracheal long-chain polyphosphate administration to C57BL/6J mice resulted in the release of proinflammatory cytokines and influx of Ly6G

Indexed as

LipopolysaccharidesNeutrophilsAnimalsBronchoalveolar Lavage FluidCytokinesEscherichia coliHumansImmunomodulationInterleukin-8LungMiceMice, Inbred C57BLPolyphosphatesCytokinesInterleukin-8LipopolysaccharidesPolyphosphatesAcute respiratory distress syndromeInfectionInflammationInnate ImmunitySepsis

Identifiers

PMID36959687
PMCPMC10666560
OpenAlexW4360812906

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.