Evidence map›Paper›PMID 36959540›Full record

ArticleBMC cancer2023

Tolerability of concurrent external beam radiotherapy and [

Esmée C A van der Sar, Arthur J A T Braat, Jochem R N van der Voort-van Zyp, Betty S van der Veen, Pim J van Leeuwen, Daphne M V de Vries-Huizing, Jeroen M A Hendrikx, Marnix G E H Lam, Wouter V Vogel

Registry-linked trialOpen access · goldFull text readClinical Trial, Phase IMulticenter Study
In one paragraph

Article in BMC cancer, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05162573 (Tolerability of Concurrent EBRT + Lu-PSMA for Node-positive Prostate Cancer), which is not on this map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05162573 phase1completednot on this map

Tolerability of Concurrent EBRT + Lu-PSMA for Node-positive Prostate Cancer (PROQURE-1)

TypeinterventionalSponsorThe Netherlands Cancer InstituteRan2021 to 2025Enrolled14ConditionsProstatic NeoplasmArms177Lu-PSMA-617, EBRT
3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Review
  3. PROQURE-I: a phase I study adding concurrent [European journal of nuclear medicine and molecular imaging · 2026
    Article
  4. The role of PSMA-based radioligand therapy in hormone-sensitive prostate cancer.European journal of nuclear medicine and molecular imaging · 2025
    Review
  5. Article
  6. A phase 1 trial to determine the maximum tolerated dose and patient-specific dosimetry of [European journal of nuclear medicine and molecular imaging · 2024
    Article
  7. Review
  8. Lesion Dosimetry for [Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2023
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Esmée C A van der SarDepartment of Radiology and Nuclear Medicine, University Medical Center Utrecht, Utrecht, The Netherlands. e.c.a.vandersar@umcutrecht.nl.ORCID http://orcid.org/0000-0003-4406-2409
Arthur J A T BraatDepartment of Radiology and Nuclear Medicine, University Medical Center Utrecht, Utrecht, The Netherlands.
Jochem R N van der Voort-van ZypDepartment of Radiation Oncology, University Medical Center Utrecht, Utrecht, The Netherlands.
Betty S van der VeenDepartment of Radiation Oncology, Netherlands Cancer Institute NKI-AVL, Amsterdam, The Netherlands.
Pim J van LeeuwenDepartment of Urology, Netherlands Cancer Institute NKI-AVL, Amsterdam, The Netherlands.
Daphne M V de Vries-HuizingDepartment Nuclear Medicine, Netherlands Cancer Institute NKI-AVL, Amsterdam, The Netherlands.
Jeroen M A HendrikxDepartment Nuclear Medicine, Netherlands Cancer Institute NKI-AVL, Amsterdam, The Netherlands.
Marnix G E H LamDepartment of Radiology and Nuclear Medicine, University Medical Center Utrecht, Utrecht, The Netherlands.
Wouter V VogelDepartment of Radiation Oncology, Netherlands Cancer Institute NKI-AVL, Amsterdam, The Netherlands.
The Netherlands Cancer Institute · NLUniversity Medical Center Utrecht · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundProstate cancer patients with locoregional lymph node disease at diagnosis (N1M0) still have a limited prognosis despite the improvements provided by aggressive curative intent multimodal locoregional external beam radiation therapy (EBRT) with systemic androgen deprivation therapy (ADT). Although some patients can be cured and the majority of patients have a long survival, the 5-year biochemical failure rate is currently 29-47%. [

methodsThe PROQURE-I study is a multicenter prospective phase I study investigating standard of care treatment (7 weeks EBRT and 3 years ADT) complemented with one concurrent cycle (three, six, or nine GBq) of systemic [ DISCUSSION: This is the first prospective study to combine EBRT and ADT with [

trial registrationClinicalTrials, NCT05162573 . Registered 7 October 2021.

Indexed as

Prostatic Neoplasms, Castration-ResistantQuality of LifeAndrogen AntagonistsBayes TheoremDipeptidesHeterocyclic Compounds, 1-RingHumansLutetiumMaleProspective StudiesProstate-Specific AntigenRadioisotopesTreatment OutcomeAndrogen AntagonistsDipeptidesHeterocyclic Compounds, 1-RingLutetiumLutetium-177Prostate-Specific AntigenPSMA-617RadioisotopesLu-PSMANode-positiveProstate cancer

Identifiers

PMID36959540
PMCPMC10035228
OpenAlexW4360613784

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read42
identifiers read4
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.